A Natural Polyphenol Exerts Antitumor Activity and Circumvents Anti–PD-1 Resistance through Effects on the Gut Microbiota

Several approaches to manipulate the gut microbiome for improving the activity of cancer immune-checkpoint inhibitors (ICI) are currently under evaluation. Here, we show that oral supplementation with the polyphenol-rich berry camu-camu (CC; Myrciaria dubia) in mice shifted gut microbial composition...

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Detalles Bibliográficos
Autores principales: Messaoudene, Meriem, Pidgeon, Reilly, Richard, Corentin, Ponce, Mayra, Diop, Khoudia, Benlaifaoui, Myriam, Nolin-Lapalme, Alexis, Cauchois, Florent, Malo, Julie, Belkaid, Wiam, Isnard, Stephane, Fradet, Yves, Dridi, Lharbi, Velin, Dominique, Oster, Paul, Raoult, Didier, Ghiringhelli, François, Boidot, Romain, Chevrier, Sandy, Kysela, David T., Brun, Yves V., Falcone, Emilia Liana, Pilon, Geneviève, Oñate, Florian Plaza, Gitton-Quent, Oscar, Le Chatelier, Emmanuelle, Durand, Sylvere, Kroemer, Guido, Elkrief, Arielle, Marette, André, Castagner, Bastien, Routy, Bertrand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394387/
https://www.ncbi.nlm.nih.gov/pubmed/35031549
http://dx.doi.org/10.1158/2159-8290.CD-21-0808

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