Integrated Multiomic Profiling Identifies the Epigenetic Regulator PRC2 as a Therapeutic Target to Counteract Leukemia Immune Escape and Relapse

Immune escape represents a major driver of acute myeloid leukemia (AML) reemergence after allogeneic hematopoietic cell transplantation (allo-HCT), with up to 40% of relapses prompted by nongenomic loss of HLA class II expression in leukemia cells. By integrative analysis of gene expression, DNA met...

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Detalles Bibliográficos
Autores principales: Gambacorta, Valentina, Beretta, Stefano, Ciccimarra, Martina, Zito, Laura, Giannetti, Kety, Andrisani, Angela, Gnani, Daniela, Zanotti, Lucia, Oliveira, Giacomo, Carrabba, Matteo Giovanni, Cittaro, Davide, Merelli, Ivan, Ciceri, Fabio, Di Micco, Raffaella, Vago, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Briefs
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394393/
https://www.ncbi.nlm.nih.gov/pubmed/35255120
http://dx.doi.org/10.1158/2159-8290.CD-21-0980

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