Cargando…

NMR and Metabolomics—A Roadmap for the Future

Metabolomics investigates global metabolic alterations associated with chemical, biological, physiological, or pathological processes. These metabolic changes are measured with various analytical platforms including liquid chromatography-mass spectrometry (LC-MS), gas chromatography-mass spectrometr...

Descripción completa

Detalles Bibliográficos
Autores principales: Wishart, David S., Cheng, Leo L., Copié, Valérie, Edison, Arthur S., Eghbalnia, Hamid R., Hoch, Jeffrey C., Gouveia, Goncalo J., Pathmasiri, Wimal, Powers, Robert, Schock, Tracey B., Sumner, Lloyd W., Uchimiya, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394421/
https://www.ncbi.nlm.nih.gov/pubmed/35893244
http://dx.doi.org/10.3390/metabo12080678
_version_ 1784771486489247744
author Wishart, David S.
Cheng, Leo L.
Copié, Valérie
Edison, Arthur S.
Eghbalnia, Hamid R.
Hoch, Jeffrey C.
Gouveia, Goncalo J.
Pathmasiri, Wimal
Powers, Robert
Schock, Tracey B.
Sumner, Lloyd W.
Uchimiya, Mario
author_facet Wishart, David S.
Cheng, Leo L.
Copié, Valérie
Edison, Arthur S.
Eghbalnia, Hamid R.
Hoch, Jeffrey C.
Gouveia, Goncalo J.
Pathmasiri, Wimal
Powers, Robert
Schock, Tracey B.
Sumner, Lloyd W.
Uchimiya, Mario
author_sort Wishart, David S.
collection PubMed
description Metabolomics investigates global metabolic alterations associated with chemical, biological, physiological, or pathological processes. These metabolic changes are measured with various analytical platforms including liquid chromatography-mass spectrometry (LC-MS), gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance spectroscopy (NMR). While LC-MS methods are becoming increasingly popular in the field of metabolomics (accounting for more than 70% of published metabolomics studies to date), there are considerable benefits and advantages to NMR-based methods for metabolomic studies. In fact, according to PubMed, more than 926 papers on NMR-based metabolomics were published in 2021—the most ever published in a given year. This suggests that NMR-based metabolomics continues to grow and has plenty to offer to the scientific community. This perspective outlines the growing applications of NMR in metabolomics, highlights several recent advances in NMR technologies for metabolomics, and provides a roadmap for future advancements.
format Online
Article
Text
id pubmed-9394421
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-93944212022-08-23 NMR and Metabolomics—A Roadmap for the Future Wishart, David S. Cheng, Leo L. Copié, Valérie Edison, Arthur S. Eghbalnia, Hamid R. Hoch, Jeffrey C. Gouveia, Goncalo J. Pathmasiri, Wimal Powers, Robert Schock, Tracey B. Sumner, Lloyd W. Uchimiya, Mario Metabolites Review Metabolomics investigates global metabolic alterations associated with chemical, biological, physiological, or pathological processes. These metabolic changes are measured with various analytical platforms including liquid chromatography-mass spectrometry (LC-MS), gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance spectroscopy (NMR). While LC-MS methods are becoming increasingly popular in the field of metabolomics (accounting for more than 70% of published metabolomics studies to date), there are considerable benefits and advantages to NMR-based methods for metabolomic studies. In fact, according to PubMed, more than 926 papers on NMR-based metabolomics were published in 2021—the most ever published in a given year. This suggests that NMR-based metabolomics continues to grow and has plenty to offer to the scientific community. This perspective outlines the growing applications of NMR in metabolomics, highlights several recent advances in NMR technologies for metabolomics, and provides a roadmap for future advancements. MDPI 2022-07-23 /pmc/articles/PMC9394421/ /pubmed/35893244 http://dx.doi.org/10.3390/metabo12080678 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wishart, David S.
Cheng, Leo L.
Copié, Valérie
Edison, Arthur S.
Eghbalnia, Hamid R.
Hoch, Jeffrey C.
Gouveia, Goncalo J.
Pathmasiri, Wimal
Powers, Robert
Schock, Tracey B.
Sumner, Lloyd W.
Uchimiya, Mario
NMR and Metabolomics—A Roadmap for the Future
title NMR and Metabolomics—A Roadmap for the Future
title_full NMR and Metabolomics—A Roadmap for the Future
title_fullStr NMR and Metabolomics—A Roadmap for the Future
title_full_unstemmed NMR and Metabolomics—A Roadmap for the Future
title_short NMR and Metabolomics—A Roadmap for the Future
title_sort nmr and metabolomics—a roadmap for the future
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394421/
https://www.ncbi.nlm.nih.gov/pubmed/35893244
http://dx.doi.org/10.3390/metabo12080678
work_keys_str_mv AT wishartdavids nmrandmetabolomicsaroadmapforthefuture
AT chengleol nmrandmetabolomicsaroadmapforthefuture
AT copievalerie nmrandmetabolomicsaroadmapforthefuture
AT edisonarthurs nmrandmetabolomicsaroadmapforthefuture
AT eghbalniahamidr nmrandmetabolomicsaroadmapforthefuture
AT hochjeffreyc nmrandmetabolomicsaroadmapforthefuture
AT gouveiagoncaloj nmrandmetabolomicsaroadmapforthefuture
AT pathmasiriwimal nmrandmetabolomicsaroadmapforthefuture
AT powersrobert nmrandmetabolomicsaroadmapforthefuture
AT schocktraceyb nmrandmetabolomicsaroadmapforthefuture
AT sumnerlloydw nmrandmetabolomicsaroadmapforthefuture
AT uchimiyamario nmrandmetabolomicsaroadmapforthefuture