Intranasal Immunization with a Vaccinia Virus Vaccine Vector Expressing Pre-Fusion Stabilized SARS-CoV-2 Spike Fully Protected Mice against Lethal Challenge with the Heavily Mutated Mouse-Adapted SARS2-N501Y(MA30) Strain of SARS-CoV-2

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The Omicron SARS-CoV-2 variant has been designated as a variant of concern because its spike protein is heavily mutated. In particular, the Omicron spike is mutated at five positions (K417, N440, E484, Q493, and N501) that have been associated with escape from neutralizing antibodies induced by eith...

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Detalles Bibliográficos
Autores principales: Kibler, Karen V., Szczerba, Mateusz, Lake, Douglas, Roeder, Alexa J., Rahman, Masmudur, Hogue, Brenda G., Roy Wong, Lok-Yin, Perlman, Stanley, Li, Yize, Jacobs, Bertram L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394475/
https://www.ncbi.nlm.nih.gov/pubmed/35893821
http://dx.doi.org/10.3390/vaccines10081172
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