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Prevalence and characterization of pain in patients with Charcot-Marie-Tooth disease type 1A
BACKGROUND: Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common form of hereditary neuropathy. OBJECTIVE: To investigate the prevalence and characteristics of pain in patients with CMT1A. METHODS: Nineteen patients with a diagnosis of CMT1A were evaluated between September 2018 and Octobe...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Academia Brasileira de Neurologia - ABNEURO
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394555/ https://www.ncbi.nlm.nih.gov/pubmed/34037101 http://dx.doi.org/10.1590/0004-282X-ANP-2020-0132 |
Sumario: | BACKGROUND: Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common form of hereditary neuropathy. OBJECTIVE: To investigate the prevalence and characteristics of pain in patients with CMT1A. METHODS: Nineteen patients with a diagnosis of CMT1A were evaluated between September 2018 and October 2019, and other causes of neuropathy were ruled out. The following tools were used for the pain assessment: neurological assessment, LANSS, DN4, clinical evaluation, VAS, CMTNS2 and SF-36. Statistical analysis was performed using prevalence analysis, t test, chi-square test and Spearman's rho. RESULTS: The prevalence of pain was 84.2% in the sample of this study, with moderate intensity and nociceptive characteristics according to the LANSS scale (75%) and clinical evaluation (50%), but differing from DN4, which found neuropathic pain in the majority of the patients (56.2%). Mixed pain was also observed in 43.7% of the patients, according to clinical criteria. There was a statistically significant correlation between pain intensity and SF-36, thus demonstrating that the lower the pain was, the lower the impairment was, in all domains. CONCLUSION: Pain is a prevalent and important symptom in CMT1A, with moderate intensity and nociceptive characteristics according to two tools, but neuropathic pain is also present, and there may even be a mixed pattern of pain. The correlation of the pain with SF-36 suggests that pain relief could provide improvements to the quality of life of these individuals. |
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