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Determinants of disability development in patients with multiple sclerosis

BACKGROUND: Multiple sclerosis (MS) is one of the most common chronic neurological diseases affecting the central nervous system in young adults. OBJECTIVE: To investigate demographic and clinical factors that are effective in the development of irreversible disability from the onset of MS, and to i...

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Autores principales: Kara, Fatma, Göl, Mehmet Fatih, Boz, Cavit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academia Brasileira de Neurologia - ABNEURO 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394570/
https://www.ncbi.nlm.nih.gov/pubmed/34320054
http://dx.doi.org/10.1590/0004-282X-ANP-2020-0338
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author Kara, Fatma
Göl, Mehmet Fatih
Boz, Cavit
author_facet Kara, Fatma
Göl, Mehmet Fatih
Boz, Cavit
author_sort Kara, Fatma
collection PubMed
description BACKGROUND: Multiple sclerosis (MS) is one of the most common chronic neurological diseases affecting the central nervous system in young adults. OBJECTIVE: To investigate demographic and clinical factors that are effective in the development of irreversible disability from the onset of MS, and to identify factors that affect the transformation from the relapse-remitting MS (RRMS) phase to the progressive MS (PMS) phase. METHODS: Retrospective study on 741 patients who were diagnosed with RRMS and PMS according to the McDonald criteria, and were enrolled into the Turkish MS database of the Department of Neurology MS Polyclinic, at the Faculty of Medicine, Karadeniz Technical University, in Trabzon, Turkey. Kaplan-Meier analysis was used to evaluate the time taken to reach EDSS 4 and EDSS 6 from the onset of disease, and the time taken between EDSS 4 and EDSS 6. RESULTS: Age of onset >40 years; having polysymptomatic-type onset, pyramidal or bladder-intestinal system-related first episode; ≥7 episodes in the first 5 years; and <2 years between the first two episodes were found to be effective for MS patients to reach EDSS 4 and EDSS 6. The demographic and clinical parameters that were effective for progression from EDSS 4 to EDSS 6 were: pyramidal or bladder-intestinal system-related first episode; 4‒6 episodes in the first 5 years; >2 years until start of first treatment; and smoking. CONCLUSIONS: Our findings reveal important characteristics of MS patients in our region. However, the associations between these parameters and MS pathophysiology remain to be elucidated.
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spelling pubmed-93945702022-12-08 Determinants of disability development in patients with multiple sclerosis Kara, Fatma Göl, Mehmet Fatih Boz, Cavit Arq Neuropsiquiatr Article BACKGROUND: Multiple sclerosis (MS) is one of the most common chronic neurological diseases affecting the central nervous system in young adults. OBJECTIVE: To investigate demographic and clinical factors that are effective in the development of irreversible disability from the onset of MS, and to identify factors that affect the transformation from the relapse-remitting MS (RRMS) phase to the progressive MS (PMS) phase. METHODS: Retrospective study on 741 patients who were diagnosed with RRMS and PMS according to the McDonald criteria, and were enrolled into the Turkish MS database of the Department of Neurology MS Polyclinic, at the Faculty of Medicine, Karadeniz Technical University, in Trabzon, Turkey. Kaplan-Meier analysis was used to evaluate the time taken to reach EDSS 4 and EDSS 6 from the onset of disease, and the time taken between EDSS 4 and EDSS 6. RESULTS: Age of onset >40 years; having polysymptomatic-type onset, pyramidal or bladder-intestinal system-related first episode; ≥7 episodes in the first 5 years; and <2 years between the first two episodes were found to be effective for MS patients to reach EDSS 4 and EDSS 6. The demographic and clinical parameters that were effective for progression from EDSS 4 to EDSS 6 were: pyramidal or bladder-intestinal system-related first episode; 4‒6 episodes in the first 5 years; >2 years until start of first treatment; and smoking. CONCLUSIONS: Our findings reveal important characteristics of MS patients in our region. However, the associations between these parameters and MS pathophysiology remain to be elucidated. Academia Brasileira de Neurologia - ABNEURO 2021-06-23 /pmc/articles/PMC9394570/ /pubmed/34320054 http://dx.doi.org/10.1590/0004-282X-ANP-2020-0338 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Kara, Fatma
Göl, Mehmet Fatih
Boz, Cavit
Determinants of disability development in patients with multiple sclerosis
title Determinants of disability development in patients with multiple sclerosis
title_full Determinants of disability development in patients with multiple sclerosis
title_fullStr Determinants of disability development in patients with multiple sclerosis
title_full_unstemmed Determinants of disability development in patients with multiple sclerosis
title_short Determinants of disability development in patients with multiple sclerosis
title_sort determinants of disability development in patients with multiple sclerosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394570/
https://www.ncbi.nlm.nih.gov/pubmed/34320054
http://dx.doi.org/10.1590/0004-282X-ANP-2020-0338
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