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Composite carotid intima-media thickness as a risk predictor of coronary heart disease in a selected population in Sri Lanka
BACKGROUND: Segment-specific variations of carotid intima-media thickness (CIMT) have not been assessed in South Asian populations. The purpose of this study was to determine if segment-specific CIMTs or a composite-CIMT score is a better risk predictor of coronary heart disease in South Asian popul...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394829/ https://www.ncbi.nlm.nih.gov/pubmed/35994446 http://dx.doi.org/10.1371/journal.pone.0271986 |
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author | Abeysuriya, Visula Wijesinha, Nirmala A. I. Priyadharshan, Prakash P. Chandrasena, Lal G. Wickremasinghe, Ananda Rajitha |
author_facet | Abeysuriya, Visula Wijesinha, Nirmala A. I. Priyadharshan, Prakash P. Chandrasena, Lal G. Wickremasinghe, Ananda Rajitha |
author_sort | Abeysuriya, Visula |
collection | PubMed |
description | BACKGROUND: Segment-specific variations of carotid intima-media thickness (CIMT) have not been assessed in South Asian populations. The purpose of this study was to determine if segment-specific CIMTs or a composite-CIMT score is a better risk predictor of coronary heart disease in South Asian populations. METHODS: A comparative prospective study was conducted from November 2019 to October 2020 in a hospital in Colombo, Sri Lanka. Based on pre-defined inclusion and exclusion criteria, cases (having a diagnosis of Coronary Heart Disease (CHD), n = 338) and controls (non-CHD group, n = 356) were recruited. Ultrasound examination of the common carotid (CCA), the carotid bulb (CB) and the internal carotid segments (ICA) of the carotid vessels was conducted by a radiologist, and CIMTs were measured. A composite-CIMT score defined as the average value of all six segments of the left and right sides was derived. RESULTS: 694 participants were enrolled (male n = 399, 57.5%). The mean (±SD) age of the study sample was 60.2 (±9.86) years. There were variations in segment-specific values between the left and right vessels. The mean composite-CIMT value of the CHD group was significantly higher than that of the non-CHD group. A composite-CIMT score of 0.758 had a sensitivity of 98.4% and a specificity of 64.6% in distinguishing CHD from non-CHD groups (Area under the curve (AUC): 0.926). CONCLUSIONS: Carotid artery segment-specific CIMT variations were present in this population. The composite CIMT score is better than segment-specific CIMTs in predicting CHD and may be used to predict CHD in this population. |
format | Online Article Text |
id | pubmed-9394829 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-93948292022-08-23 Composite carotid intima-media thickness as a risk predictor of coronary heart disease in a selected population in Sri Lanka Abeysuriya, Visula Wijesinha, Nirmala A. I. Priyadharshan, Prakash P. Chandrasena, Lal G. Wickremasinghe, Ananda Rajitha PLoS One Research Article BACKGROUND: Segment-specific variations of carotid intima-media thickness (CIMT) have not been assessed in South Asian populations. The purpose of this study was to determine if segment-specific CIMTs or a composite-CIMT score is a better risk predictor of coronary heart disease in South Asian populations. METHODS: A comparative prospective study was conducted from November 2019 to October 2020 in a hospital in Colombo, Sri Lanka. Based on pre-defined inclusion and exclusion criteria, cases (having a diagnosis of Coronary Heart Disease (CHD), n = 338) and controls (non-CHD group, n = 356) were recruited. Ultrasound examination of the common carotid (CCA), the carotid bulb (CB) and the internal carotid segments (ICA) of the carotid vessels was conducted by a radiologist, and CIMTs were measured. A composite-CIMT score defined as the average value of all six segments of the left and right sides was derived. RESULTS: 694 participants were enrolled (male n = 399, 57.5%). The mean (±SD) age of the study sample was 60.2 (±9.86) years. There were variations in segment-specific values between the left and right vessels. The mean composite-CIMT value of the CHD group was significantly higher than that of the non-CHD group. A composite-CIMT score of 0.758 had a sensitivity of 98.4% and a specificity of 64.6% in distinguishing CHD from non-CHD groups (Area under the curve (AUC): 0.926). CONCLUSIONS: Carotid artery segment-specific CIMT variations were present in this population. The composite CIMT score is better than segment-specific CIMTs in predicting CHD and may be used to predict CHD in this population. Public Library of Science 2022-08-22 /pmc/articles/PMC9394829/ /pubmed/35994446 http://dx.doi.org/10.1371/journal.pone.0271986 Text en © 2022 Abeysuriya et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Abeysuriya, Visula Wijesinha, Nirmala A. I. Priyadharshan, Prakash P. Chandrasena, Lal G. Wickremasinghe, Ananda Rajitha Composite carotid intima-media thickness as a risk predictor of coronary heart disease in a selected population in Sri Lanka |
title | Composite carotid intima-media thickness as a risk predictor of coronary heart disease in a selected population in Sri Lanka |
title_full | Composite carotid intima-media thickness as a risk predictor of coronary heart disease in a selected population in Sri Lanka |
title_fullStr | Composite carotid intima-media thickness as a risk predictor of coronary heart disease in a selected population in Sri Lanka |
title_full_unstemmed | Composite carotid intima-media thickness as a risk predictor of coronary heart disease in a selected population in Sri Lanka |
title_short | Composite carotid intima-media thickness as a risk predictor of coronary heart disease in a selected population in Sri Lanka |
title_sort | composite carotid intima-media thickness as a risk predictor of coronary heart disease in a selected population in sri lanka |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394829/ https://www.ncbi.nlm.nih.gov/pubmed/35994446 http://dx.doi.org/10.1371/journal.pone.0271986 |
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