Cargando…
Fingolimod mitigates synaptic deficits and psychosis‐like behavior in APP/PSEN1 mice
INTRODUCTION: Current treatments for psychosis in Alzheimer's disease (AD), a syndrome characterized by more rapid deterioration and reduced synaptic protein abundance relative to non‐psychotic AD, are inadequate. Fingolimod, a currently US Food and Drug Administration (FDA)–approved pharmacoth...
Autores principales: | Krivinko, Josh M., Erickson, Susan L., MacDonald, Matthew L., Garver, Megan E., Sweet, Robert A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395154/ https://www.ncbi.nlm.nih.gov/pubmed/36016832 http://dx.doi.org/10.1002/trc2.12324 |
Ejemplares similares
-
Targeting the post-synaptic proteome has therapeutic potential for psychosis in Alzheimer Disease
por: Krivinko, J. M., et al.
Publicado: (2023) -
Psychosis in Alzheimer's Disease Is Associated With Increased Excitatory Neuron Vulnerability and Post-transcriptional Mechanisms Altering Synaptic Protein Levels
por: DeChellis-Marks, Michael R., et al.
Publicado: (2022) -
Systematic validation of variants of unknown significance in APP, PSEN1 and PSEN2
por: Hsu, Simon, et al.
Publicado: (2020) -
Altered synaptic glutamate homeostasis contributes to cognitive decline in young APP/PSEN1 mice
por: Wilcox, J.M., et al.
Publicado: (2021) -
APP, PSEN1, and PSEN2 Mutations in Asian Patients with Early-Onset Alzheimer Disease
por: Giau, Vo Van, et al.
Publicado: (2019)