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The Role of TAMs in Tumor Microenvironment and New Research Progress
Tumor-associated macrophages (TAMs) are an important part of tumor microenvironment (TME) and play a key role in TME, participating in the process of tumor occurrence, growth, invasion, and metastasis. Among them, metastasis to tumor tissue is the key step of malignant development of tumor. In this...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395242/ https://www.ncbi.nlm.nih.gov/pubmed/36004381 http://dx.doi.org/10.1155/2022/5775696 |
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author | Feng, Yawei Ye, Zhiqiang Song, Furong He, Yufeng Liu, Jun |
author_facet | Feng, Yawei Ye, Zhiqiang Song, Furong He, Yufeng Liu, Jun |
author_sort | Feng, Yawei |
collection | PubMed |
description | Tumor-associated macrophages (TAMs) are an important part of tumor microenvironment (TME) and play a key role in TME, participating in the process of tumor occurrence, growth, invasion, and metastasis. Among them, metastasis to tumor tissue is the key step of malignant development of tumor. In this paper, the latest progress in the role of TAMs in the formation of tumor microenvironment is summarized. It is particularly noteworthy that cell and animal experiments show that TAMs can provide a favorable microenvironment for the occurrence and development of tumors. At the same time, clinical pathological experiments show that the accumulation of TAMs in tumor is related to poor clinical efficacy. Finally, this paper discusses the feasibility of TAMs-targeted therapy as a new indirect cancer therapy. This paper provides a theoretical basis for finding a potentially effective macrophage-targeted tumor therapy. |
format | Online Article Text |
id | pubmed-9395242 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-93952422022-08-23 The Role of TAMs in Tumor Microenvironment and New Research Progress Feng, Yawei Ye, Zhiqiang Song, Furong He, Yufeng Liu, Jun Stem Cells Int Research Article Tumor-associated macrophages (TAMs) are an important part of tumor microenvironment (TME) and play a key role in TME, participating in the process of tumor occurrence, growth, invasion, and metastasis. Among them, metastasis to tumor tissue is the key step of malignant development of tumor. In this paper, the latest progress in the role of TAMs in the formation of tumor microenvironment is summarized. It is particularly noteworthy that cell and animal experiments show that TAMs can provide a favorable microenvironment for the occurrence and development of tumors. At the same time, clinical pathological experiments show that the accumulation of TAMs in tumor is related to poor clinical efficacy. Finally, this paper discusses the feasibility of TAMs-targeted therapy as a new indirect cancer therapy. This paper provides a theoretical basis for finding a potentially effective macrophage-targeted tumor therapy. Hindawi 2022-08-15 /pmc/articles/PMC9395242/ /pubmed/36004381 http://dx.doi.org/10.1155/2022/5775696 Text en Copyright © 2022 Yawei Feng et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Feng, Yawei Ye, Zhiqiang Song, Furong He, Yufeng Liu, Jun The Role of TAMs in Tumor Microenvironment and New Research Progress |
title | The Role of TAMs in Tumor Microenvironment and New Research Progress |
title_full | The Role of TAMs in Tumor Microenvironment and New Research Progress |
title_fullStr | The Role of TAMs in Tumor Microenvironment and New Research Progress |
title_full_unstemmed | The Role of TAMs in Tumor Microenvironment and New Research Progress |
title_short | The Role of TAMs in Tumor Microenvironment and New Research Progress |
title_sort | role of tams in tumor microenvironment and new research progress |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395242/ https://www.ncbi.nlm.nih.gov/pubmed/36004381 http://dx.doi.org/10.1155/2022/5775696 |
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