Cargando…

The Role of TAMs in Tumor Microenvironment and New Research Progress

Tumor-associated macrophages (TAMs) are an important part of tumor microenvironment (TME) and play a key role in TME, participating in the process of tumor occurrence, growth, invasion, and metastasis. Among them, metastasis to tumor tissue is the key step of malignant development of tumor. In this...

Descripción completa

Detalles Bibliográficos
Autores principales: Feng, Yawei, Ye, Zhiqiang, Song, Furong, He, Yufeng, Liu, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395242/
https://www.ncbi.nlm.nih.gov/pubmed/36004381
http://dx.doi.org/10.1155/2022/5775696
_version_ 1784771646728437760
author Feng, Yawei
Ye, Zhiqiang
Song, Furong
He, Yufeng
Liu, Jun
author_facet Feng, Yawei
Ye, Zhiqiang
Song, Furong
He, Yufeng
Liu, Jun
author_sort Feng, Yawei
collection PubMed
description Tumor-associated macrophages (TAMs) are an important part of tumor microenvironment (TME) and play a key role in TME, participating in the process of tumor occurrence, growth, invasion, and metastasis. Among them, metastasis to tumor tissue is the key step of malignant development of tumor. In this paper, the latest progress in the role of TAMs in the formation of tumor microenvironment is summarized. It is particularly noteworthy that cell and animal experiments show that TAMs can provide a favorable microenvironment for the occurrence and development of tumors. At the same time, clinical pathological experiments show that the accumulation of TAMs in tumor is related to poor clinical efficacy. Finally, this paper discusses the feasibility of TAMs-targeted therapy as a new indirect cancer therapy. This paper provides a theoretical basis for finding a potentially effective macrophage-targeted tumor therapy.
format Online
Article
Text
id pubmed-9395242
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-93952422022-08-23 The Role of TAMs in Tumor Microenvironment and New Research Progress Feng, Yawei Ye, Zhiqiang Song, Furong He, Yufeng Liu, Jun Stem Cells Int Research Article Tumor-associated macrophages (TAMs) are an important part of tumor microenvironment (TME) and play a key role in TME, participating in the process of tumor occurrence, growth, invasion, and metastasis. Among them, metastasis to tumor tissue is the key step of malignant development of tumor. In this paper, the latest progress in the role of TAMs in the formation of tumor microenvironment is summarized. It is particularly noteworthy that cell and animal experiments show that TAMs can provide a favorable microenvironment for the occurrence and development of tumors. At the same time, clinical pathological experiments show that the accumulation of TAMs in tumor is related to poor clinical efficacy. Finally, this paper discusses the feasibility of TAMs-targeted therapy as a new indirect cancer therapy. This paper provides a theoretical basis for finding a potentially effective macrophage-targeted tumor therapy. Hindawi 2022-08-15 /pmc/articles/PMC9395242/ /pubmed/36004381 http://dx.doi.org/10.1155/2022/5775696 Text en Copyright © 2022 Yawei Feng et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Feng, Yawei
Ye, Zhiqiang
Song, Furong
He, Yufeng
Liu, Jun
The Role of TAMs in Tumor Microenvironment and New Research Progress
title The Role of TAMs in Tumor Microenvironment and New Research Progress
title_full The Role of TAMs in Tumor Microenvironment and New Research Progress
title_fullStr The Role of TAMs in Tumor Microenvironment and New Research Progress
title_full_unstemmed The Role of TAMs in Tumor Microenvironment and New Research Progress
title_short The Role of TAMs in Tumor Microenvironment and New Research Progress
title_sort role of tams in tumor microenvironment and new research progress
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395242/
https://www.ncbi.nlm.nih.gov/pubmed/36004381
http://dx.doi.org/10.1155/2022/5775696
work_keys_str_mv AT fengyawei theroleoftamsintumormicroenvironmentandnewresearchprogress
AT yezhiqiang theroleoftamsintumormicroenvironmentandnewresearchprogress
AT songfurong theroleoftamsintumormicroenvironmentandnewresearchprogress
AT heyufeng theroleoftamsintumormicroenvironmentandnewresearchprogress
AT liujun theroleoftamsintumormicroenvironmentandnewresearchprogress
AT fengyawei roleoftamsintumormicroenvironmentandnewresearchprogress
AT yezhiqiang roleoftamsintumormicroenvironmentandnewresearchprogress
AT songfurong roleoftamsintumormicroenvironmentandnewresearchprogress
AT heyufeng roleoftamsintumormicroenvironmentandnewresearchprogress
AT liujun roleoftamsintumormicroenvironmentandnewresearchprogress