Honghua extract mediated potent inhibition of COVID-19 host cell pathways

Honghua (Carthami flos) and Xihonghua (Croci stigma) have been used in anti-COVID-19 as Traditional Chinese Medicine, but the mechanism is unclear. In this study, we applied network pharmacology by analysis of active compounds and compound-targets networks, enzyme kinetics assay, signaling pathway a...

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Autores principales: Madikyzy, Malika, Tilegen, Meruyert, Nazarbek, Guldan, Mu, Chenglin, Kutzhanova, Aidana, Li, Xugang, Ma, Cuiping, Xie, Yingqiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395372/
https://www.ncbi.nlm.nih.gov/pubmed/35995784
http://dx.doi.org/10.1038/s41598-022-15338-9
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author Madikyzy, Malika
Tilegen, Meruyert
Nazarbek, Guldan
Mu, Chenglin
Kutzhanova, Aidana
Li, Xugang
Ma, Cuiping
Xie, Yingqiu
author_facet Madikyzy, Malika
Tilegen, Meruyert
Nazarbek, Guldan
Mu, Chenglin
Kutzhanova, Aidana
Li, Xugang
Ma, Cuiping
Xie, Yingqiu
author_sort Madikyzy, Malika
collection PubMed
description Honghua (Carthami flos) and Xihonghua (Croci stigma) have been used in anti-COVID-19 as Traditional Chinese Medicine, but the mechanism is unclear. In this study, we applied network pharmacology by analysis of active compounds and compound-targets networks, enzyme kinetics assay, signaling pathway analysis and investigated the potential mechanisms of anti-COVID-19. We found that both herbs act on signaling including kinases, response to inflammation and virus. Moreover, crocin likely has an antiviral effect due to its high affinity towards the human ACE2 receptor by simulation. The extract of Honghua and Xihonghua exhibited nanozyme/herbzyme activity of alkaline phosphatase, with distinct fluorescence. Thus, our data suggest the great potential of Honghua in the development of anti-COVID-19 agents.
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spelling pubmed-93953722022-08-23 Honghua extract mediated potent inhibition of COVID-19 host cell pathways Madikyzy, Malika Tilegen, Meruyert Nazarbek, Guldan Mu, Chenglin Kutzhanova, Aidana Li, Xugang Ma, Cuiping Xie, Yingqiu Sci Rep Article Honghua (Carthami flos) and Xihonghua (Croci stigma) have been used in anti-COVID-19 as Traditional Chinese Medicine, but the mechanism is unclear. In this study, we applied network pharmacology by analysis of active compounds and compound-targets networks, enzyme kinetics assay, signaling pathway analysis and investigated the potential mechanisms of anti-COVID-19. We found that both herbs act on signaling including kinases, response to inflammation and virus. Moreover, crocin likely has an antiviral effect due to its high affinity towards the human ACE2 receptor by simulation. The extract of Honghua and Xihonghua exhibited nanozyme/herbzyme activity of alkaline phosphatase, with distinct fluorescence. Thus, our data suggest the great potential of Honghua in the development of anti-COVID-19 agents. Nature Publishing Group UK 2022-08-22 /pmc/articles/PMC9395372/ /pubmed/35995784 http://dx.doi.org/10.1038/s41598-022-15338-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Madikyzy, Malika
Tilegen, Meruyert
Nazarbek, Guldan
Mu, Chenglin
Kutzhanova, Aidana
Li, Xugang
Ma, Cuiping
Xie, Yingqiu
Honghua extract mediated potent inhibition of COVID-19 host cell pathways
title Honghua extract mediated potent inhibition of COVID-19 host cell pathways
title_full Honghua extract mediated potent inhibition of COVID-19 host cell pathways
title_fullStr Honghua extract mediated potent inhibition of COVID-19 host cell pathways
title_full_unstemmed Honghua extract mediated potent inhibition of COVID-19 host cell pathways
title_short Honghua extract mediated potent inhibition of COVID-19 host cell pathways
title_sort honghua extract mediated potent inhibition of covid-19 host cell pathways
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395372/
https://www.ncbi.nlm.nih.gov/pubmed/35995784
http://dx.doi.org/10.1038/s41598-022-15338-9
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