The antileukemic activity of decitabine upon PML/RARA-negative AML blasts is supported by all-trans retinoic acid: in vitro and in vivo evidence for cooperation

The prognosis of AML patients with adverse genetics, such as a complex, monosomal karyotype and TP53 lesions, is still dismal even with standard chemotherapy. DNA-hypomethylating agent monotherapy induces an encouraging response rate in these patients. When combined with decitabine (DAC), all-trans...

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Detalles Bibliográficos
Autores principales: Meier, Ruth, Greve, Gabriele, Zimmer, Dennis, Bresser, Helena, Berberich, Bettina, Langova, Ralitsa, Stomper, Julia, Rubarth, Anne, Feuerbach, Lars, Lipka, Daniel B., Hey, Joschka, Grüning, Björn, Brors, Benedikt, Duyster, Justus, Plass, Christoph, Becker, Heiko, Lübbert, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395383/
https://www.ncbi.nlm.nih.gov/pubmed/35995769
http://dx.doi.org/10.1038/s41408-022-00715-4

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