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Prevalence and antimicrobial resistance patterns of microbes isolated from individuals attending private diagnostic centre in Cape Coast Metropolis of Ghana

The evidence of rising numbers of multidrug-resistant organisms requires the implementation of effective stewardship programs. However, this should be informed by evidence-based knowledge of local antimicrobial resistance patterns. The current study aims to establish the prevalence of common pathoge...

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Autores principales: Anning, Alberta Serwah, Baah, Emmanuel, Buabeng, Suzzana Dickson, Baiden, Bernice Gloria, Aboagye, Benjamin, Opoku, Yeboah Kwaku, Afutu, Leslie Larry, Ghartey-Kwansah, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395395/
https://www.ncbi.nlm.nih.gov/pubmed/35995932
http://dx.doi.org/10.1038/s41598-022-18595-w
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author Anning, Alberta Serwah
Baah, Emmanuel
Buabeng, Suzzana Dickson
Baiden, Bernice Gloria
Aboagye, Benjamin
Opoku, Yeboah Kwaku
Afutu, Leslie Larry
Ghartey-Kwansah, George
author_facet Anning, Alberta Serwah
Baah, Emmanuel
Buabeng, Suzzana Dickson
Baiden, Bernice Gloria
Aboagye, Benjamin
Opoku, Yeboah Kwaku
Afutu, Leslie Larry
Ghartey-Kwansah, George
author_sort Anning, Alberta Serwah
collection PubMed
description The evidence of rising numbers of multidrug-resistant organisms requires the implementation of effective stewardship programs. However, this should be informed by evidence-based knowledge of local antimicrobial resistance patterns. The current study aims to establish the prevalence of common pathogenic microbes including their antimicrobial susceptibility patterns and distribution in the Cape Coast Metropolis. This was a retrospective study where microbial culture and antimicrobial susceptibility records for 331 patients were reviewed from January to December 2019, at a private health centre. All data were analysed using Excel (Microsoft Office, USA), SPSS and GraphPad Prism 8 software programs. Among the samples tested, 125 (37.76%) were positive for microbes with high vaginal swab (HVS) samples recording the highest number of pathogens (44%), followed by urine (40%) and both pleural and semen samples having the least (0.3% each). Again, gram-negative isolates were more prevalent than the gram-positive isolates. The prevalence of antimicrobial resistance was very significant with isolates resistant to more than one antibiotic (P < 0.05). Escherichia coli showed the highest level of resistance, followed by Citrobacter spp. These were followed by Klebsiella spp., Staphylococcus spp., Coliforms, Pseudomonas spp., Commensals and Candida spp. The high resistance pattern suggests an inevitable catastrophe requiring continuous monitoring and implementation of effective antibiotic stewardship.
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spelling pubmed-93953952022-08-24 Prevalence and antimicrobial resistance patterns of microbes isolated from individuals attending private diagnostic centre in Cape Coast Metropolis of Ghana Anning, Alberta Serwah Baah, Emmanuel Buabeng, Suzzana Dickson Baiden, Bernice Gloria Aboagye, Benjamin Opoku, Yeboah Kwaku Afutu, Leslie Larry Ghartey-Kwansah, George Sci Rep Article The evidence of rising numbers of multidrug-resistant organisms requires the implementation of effective stewardship programs. However, this should be informed by evidence-based knowledge of local antimicrobial resistance patterns. The current study aims to establish the prevalence of common pathogenic microbes including their antimicrobial susceptibility patterns and distribution in the Cape Coast Metropolis. This was a retrospective study where microbial culture and antimicrobial susceptibility records for 331 patients were reviewed from January to December 2019, at a private health centre. All data were analysed using Excel (Microsoft Office, USA), SPSS and GraphPad Prism 8 software programs. Among the samples tested, 125 (37.76%) were positive for microbes with high vaginal swab (HVS) samples recording the highest number of pathogens (44%), followed by urine (40%) and both pleural and semen samples having the least (0.3% each). Again, gram-negative isolates were more prevalent than the gram-positive isolates. The prevalence of antimicrobial resistance was very significant with isolates resistant to more than one antibiotic (P < 0.05). Escherichia coli showed the highest level of resistance, followed by Citrobacter spp. These were followed by Klebsiella spp., Staphylococcus spp., Coliforms, Pseudomonas spp., Commensals and Candida spp. The high resistance pattern suggests an inevitable catastrophe requiring continuous monitoring and implementation of effective antibiotic stewardship. Nature Publishing Group UK 2022-08-22 /pmc/articles/PMC9395395/ /pubmed/35995932 http://dx.doi.org/10.1038/s41598-022-18595-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Anning, Alberta Serwah
Baah, Emmanuel
Buabeng, Suzzana Dickson
Baiden, Bernice Gloria
Aboagye, Benjamin
Opoku, Yeboah Kwaku
Afutu, Leslie Larry
Ghartey-Kwansah, George
Prevalence and antimicrobial resistance patterns of microbes isolated from individuals attending private diagnostic centre in Cape Coast Metropolis of Ghana
title Prevalence and antimicrobial resistance patterns of microbes isolated from individuals attending private diagnostic centre in Cape Coast Metropolis of Ghana
title_full Prevalence and antimicrobial resistance patterns of microbes isolated from individuals attending private diagnostic centre in Cape Coast Metropolis of Ghana
title_fullStr Prevalence and antimicrobial resistance patterns of microbes isolated from individuals attending private diagnostic centre in Cape Coast Metropolis of Ghana
title_full_unstemmed Prevalence and antimicrobial resistance patterns of microbes isolated from individuals attending private diagnostic centre in Cape Coast Metropolis of Ghana
title_short Prevalence and antimicrobial resistance patterns of microbes isolated from individuals attending private diagnostic centre in Cape Coast Metropolis of Ghana
title_sort prevalence and antimicrobial resistance patterns of microbes isolated from individuals attending private diagnostic centre in cape coast metropolis of ghana
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395395/
https://www.ncbi.nlm.nih.gov/pubmed/35995932
http://dx.doi.org/10.1038/s41598-022-18595-w
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