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Serum concentrations of gabapentin in cats with chronic kidney disease

OBJECTIVES: The purpose of this study was to assess serum concentrations of gabapentin in cats with chronic kidney disease (CKD) vs clinically healthy cats. METHODS: Five healthy cats were enrolled in a pharmacokinetic study. A single 20 mg/kg dose of gabapentin was administered orally and blood was...

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Autores principales: Quimby, Jessica M, Lorbach, Sarah K, Saffire, Ashlie, Kennedy, Amanda, Wittenburg, Luke A, Aarnes, Turi K, Creighton, Karina J, Jones, Sarah E, Paschall, Rene E, King, Emily M, Bruner, Clara E, Wallinger, Jessica N, van Haaften, Karen A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395545/
https://www.ncbi.nlm.nih.gov/pubmed/35195476
http://dx.doi.org/10.1177/1098612X221077017
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author Quimby, Jessica M
Lorbach, Sarah K
Saffire, Ashlie
Kennedy, Amanda
Wittenburg, Luke A
Aarnes, Turi K
Creighton, Karina J
Jones, Sarah E
Paschall, Rene E
King, Emily M
Bruner, Clara E
Wallinger, Jessica N
van Haaften, Karen A
author_facet Quimby, Jessica M
Lorbach, Sarah K
Saffire, Ashlie
Kennedy, Amanda
Wittenburg, Luke A
Aarnes, Turi K
Creighton, Karina J
Jones, Sarah E
Paschall, Rene E
King, Emily M
Bruner, Clara E
Wallinger, Jessica N
van Haaften, Karen A
author_sort Quimby, Jessica M
collection PubMed
description OBJECTIVES: The purpose of this study was to assess serum concentrations of gabapentin in cats with chronic kidney disease (CKD) vs clinically healthy cats. METHODS: Five healthy cats were enrolled in a pharmacokinetic study. A single 20 mg/kg dose of gabapentin was administered orally and blood was obtained at 0, 0.25, 0.5, 1, 1.5, 2, 3, 4, 8, 12, 24 and 36 h via a jugular catheter. Serum gabapentin concentrations were measured using liquid chromatography coupled to tandem mass spectrometry. Non-compartmental pharmacokinetic analysis was performed. The same five healthy cats plus 25 cats with stable International Renal Interest Society stage 2 (n = 14) and 3 (n = 11) CKD were enrolled in a limited sampling study. Cats in both groups received a single 10 mg/kg dose of gabapentin, and serum gabapentin concentrations and compliance scores were obtained 3 and 8 h post-administration. RESULTS: Cats with CKD had significantly higher dose-normalized serum gabapentin concentrations than normal cats at 3 h (P = 0.0012 CKD vs normal 10 mg/kg; P = 0.008 CKD vs normal 20 mg/kg) and 8 h (P <0.0001 CKD vs normal 10 mg/kg; P <0.0001 CKD vs normal 20 mg/kg). Both 3 and 8 h dose-normalized serum gabapentin concentrations were significantly correlated with serum creatinine (3 h: P = 0.03, r = 0.39; 8 h: P = 0.001, r = 0.57) and symmetric dimethylarginine (3 h: P = 0.03, r = 0.41; 8 h: P = 0.007, r = 0.48). There was a significant correlation between 3 h serum gabapentin concentrations and compliance scores (P = 0.0002, r = 0.68). CONCLUSIONS AND RELEVANCE: Cats with CKD that received 10 mg/kg of gabapentin had significantly higher dose-normalized serum concentrations than normal cats that received 20 mg/kg, supporting the need to dose-reduce in this patient population.
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spelling pubmed-93955452022-12-12 Serum concentrations of gabapentin in cats with chronic kidney disease Quimby, Jessica M Lorbach, Sarah K Saffire, Ashlie Kennedy, Amanda Wittenburg, Luke A Aarnes, Turi K Creighton, Karina J Jones, Sarah E Paschall, Rene E King, Emily M Bruner, Clara E Wallinger, Jessica N van Haaften, Karen A J Feline Med Surg Original Articles OBJECTIVES: The purpose of this study was to assess serum concentrations of gabapentin in cats with chronic kidney disease (CKD) vs clinically healthy cats. METHODS: Five healthy cats were enrolled in a pharmacokinetic study. A single 20 mg/kg dose of gabapentin was administered orally and blood was obtained at 0, 0.25, 0.5, 1, 1.5, 2, 3, 4, 8, 12, 24 and 36 h via a jugular catheter. Serum gabapentin concentrations were measured using liquid chromatography coupled to tandem mass spectrometry. Non-compartmental pharmacokinetic analysis was performed. The same five healthy cats plus 25 cats with stable International Renal Interest Society stage 2 (n = 14) and 3 (n = 11) CKD were enrolled in a limited sampling study. Cats in both groups received a single 10 mg/kg dose of gabapentin, and serum gabapentin concentrations and compliance scores were obtained 3 and 8 h post-administration. RESULTS: Cats with CKD had significantly higher dose-normalized serum gabapentin concentrations than normal cats at 3 h (P = 0.0012 CKD vs normal 10 mg/kg; P = 0.008 CKD vs normal 20 mg/kg) and 8 h (P <0.0001 CKD vs normal 10 mg/kg; P <0.0001 CKD vs normal 20 mg/kg). Both 3 and 8 h dose-normalized serum gabapentin concentrations were significantly correlated with serum creatinine (3 h: P = 0.03, r = 0.39; 8 h: P = 0.001, r = 0.57) and symmetric dimethylarginine (3 h: P = 0.03, r = 0.41; 8 h: P = 0.007, r = 0.48). There was a significant correlation between 3 h serum gabapentin concentrations and compliance scores (P = 0.0002, r = 0.68). CONCLUSIONS AND RELEVANCE: Cats with CKD that received 10 mg/kg of gabapentin had significantly higher dose-normalized serum concentrations than normal cats that received 20 mg/kg, supporting the need to dose-reduce in this patient population. SAGE Publications 2022-02-23 2022-12 /pmc/articles/PMC9395545/ /pubmed/35195476 http://dx.doi.org/10.1177/1098612X221077017 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage)
spellingShingle Original Articles
Quimby, Jessica M
Lorbach, Sarah K
Saffire, Ashlie
Kennedy, Amanda
Wittenburg, Luke A
Aarnes, Turi K
Creighton, Karina J
Jones, Sarah E
Paschall, Rene E
King, Emily M
Bruner, Clara E
Wallinger, Jessica N
van Haaften, Karen A
Serum concentrations of gabapentin in cats with chronic kidney disease
title Serum concentrations of gabapentin in cats with chronic kidney disease
title_full Serum concentrations of gabapentin in cats with chronic kidney disease
title_fullStr Serum concentrations of gabapentin in cats with chronic kidney disease
title_full_unstemmed Serum concentrations of gabapentin in cats with chronic kidney disease
title_short Serum concentrations of gabapentin in cats with chronic kidney disease
title_sort serum concentrations of gabapentin in cats with chronic kidney disease
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395545/
https://www.ncbi.nlm.nih.gov/pubmed/35195476
http://dx.doi.org/10.1177/1098612X221077017
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