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Dosimetric Evaluation of Different Optimization Algorithms Used in Interstitial Brachytherapy of Cervical Carcinoma
BACKGROUND: Conventional optimization techniques are based on the planning approach in which positions and weights are varied to generate the desired dose distribution. Inverse planning simulated annealing (IPSA) is an advanced optimization method developed to automatically determine a suitable comb...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Shiraz University of Medical Sciences
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395632/ https://www.ncbi.nlm.nih.gov/pubmed/36059288 http://dx.doi.org/10.31661/jbpe.v0i0.2104-1306 |
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author | Srivastava, Shraddha Singh, Navin Kashyap, Varun Kumar |
author_facet | Srivastava, Shraddha Singh, Navin Kashyap, Varun Kumar |
author_sort | Srivastava, Shraddha |
collection | PubMed |
description | BACKGROUND: Conventional optimization techniques are based on the planning approach in which positions and weights are varied to generate the desired dose distribution. Inverse planning simulated annealing (IPSA) is an advanced optimization method developed to automatically determine a suitable combination of positions to design an acceptable plan. OBJECTIVE: In this study, three optimization techniques namely IPSA, graphical optimization (GROPT), and geometrical optimization (GOPT) methods are compared in high-dose-rate interstitial brachytherapy of cervical carcinoma. MATERIAL AND METHODS: In this retrospective study, twenty computed tomography (CT) data sets of 10 cervical cancer patients treated with Martinez Universal Perineal Interstitial Template-based interstitial brachytherapy were studied. The treatment plans generated were optimized using the IPSA, and GOPT methods. The prescribed dose was 24 Gy in 4 fractions. Plans produced using IPSA, GrOPT, and GOPT techniques were analyzed for comparison of dosimetric parameters, including target coverage, homogeneity, conformity, and organs at risk (OAR) doses. RESULTS: V100 values for IPSA, GrOPT and GOPT plans were 95.81±2.33%, 93.12±2.76% and 88.90±4.95%, respectively. The mean D90 values for the IPSA, GrOPT, and GOPT plans were 6.45±0.15 Gy, 6.12±0.21 Gy, and 5.85±0.57 Gy, respectively. Significantly lower doses of OAR were in the IPSA plans that were more homogeneous (HI=0.66). Conformity was comparatively higher in IPSA-based plans (CI=0.75). CONCLUSION: IPSA plans were superior and resulted in better target coverage, homogeneity, conformity, and minimal OAR doses. |
format | Online Article Text |
id | pubmed-9395632 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Shiraz University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-93956322022-09-02 Dosimetric Evaluation of Different Optimization Algorithms Used in Interstitial Brachytherapy of Cervical Carcinoma Srivastava, Shraddha Singh, Navin Kashyap, Varun Kumar J Biomed Phys Eng Original Article BACKGROUND: Conventional optimization techniques are based on the planning approach in which positions and weights are varied to generate the desired dose distribution. Inverse planning simulated annealing (IPSA) is an advanced optimization method developed to automatically determine a suitable combination of positions to design an acceptable plan. OBJECTIVE: In this study, three optimization techniques namely IPSA, graphical optimization (GROPT), and geometrical optimization (GOPT) methods are compared in high-dose-rate interstitial brachytherapy of cervical carcinoma. MATERIAL AND METHODS: In this retrospective study, twenty computed tomography (CT) data sets of 10 cervical cancer patients treated with Martinez Universal Perineal Interstitial Template-based interstitial brachytherapy were studied. The treatment plans generated were optimized using the IPSA, and GOPT methods. The prescribed dose was 24 Gy in 4 fractions. Plans produced using IPSA, GrOPT, and GOPT techniques were analyzed for comparison of dosimetric parameters, including target coverage, homogeneity, conformity, and organs at risk (OAR) doses. RESULTS: V100 values for IPSA, GrOPT and GOPT plans were 95.81±2.33%, 93.12±2.76% and 88.90±4.95%, respectively. The mean D90 values for the IPSA, GrOPT, and GOPT plans were 6.45±0.15 Gy, 6.12±0.21 Gy, and 5.85±0.57 Gy, respectively. Significantly lower doses of OAR were in the IPSA plans that were more homogeneous (HI=0.66). Conformity was comparatively higher in IPSA-based plans (CI=0.75). CONCLUSION: IPSA plans were superior and resulted in better target coverage, homogeneity, conformity, and minimal OAR doses. Shiraz University of Medical Sciences 2022-08-01 /pmc/articles/PMC9395632/ /pubmed/36059288 http://dx.doi.org/10.31661/jbpe.v0i0.2104-1306 Text en Copyright: © Journal of Biomedical Physics and Engineering https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 Unported License, ( http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Srivastava, Shraddha Singh, Navin Kashyap, Varun Kumar Dosimetric Evaluation of Different Optimization Algorithms Used in Interstitial Brachytherapy of Cervical Carcinoma |
title | Dosimetric Evaluation of Different Optimization Algorithms Used in Interstitial Brachytherapy of Cervical Carcinoma |
title_full | Dosimetric Evaluation of Different Optimization Algorithms Used in Interstitial Brachytherapy of Cervical Carcinoma |
title_fullStr | Dosimetric Evaluation of Different Optimization Algorithms Used in Interstitial Brachytherapy of Cervical Carcinoma |
title_full_unstemmed | Dosimetric Evaluation of Different Optimization Algorithms Used in Interstitial Brachytherapy of Cervical Carcinoma |
title_short | Dosimetric Evaluation of Different Optimization Algorithms Used in Interstitial Brachytherapy of Cervical Carcinoma |
title_sort | dosimetric evaluation of different optimization algorithms used in interstitial brachytherapy of cervical carcinoma |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395632/ https://www.ncbi.nlm.nih.gov/pubmed/36059288 http://dx.doi.org/10.31661/jbpe.v0i0.2104-1306 |
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