YT521-B homology domain family proteins as N6-methyladenosine readers in tumors

N6-methyladenosine (m6A) is the most abundant internal chemical modification of eukaryotic mRNA and plays diverse roles in gene regulation. The m6A modification plays a significant role in numerous cancer types, including kidney, stomach, lung, bladder tumors, and melanoma, through varied mechanisms...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Heng, Chiang, Chengyao, Luo, Qinhong, Chen, Chunlan, Huang, Junrong, Zhu, Lizhi, Zheng, Duo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395638/
https://www.ncbi.nlm.nih.gov/pubmed/36017491
http://dx.doi.org/10.3389/fgene.2022.934223
_version_ 1784771743334793216
author Yang, Heng
Chiang, Chengyao
Luo, Qinhong
Chen, Chunlan
Huang, Junrong
Zhu, Lizhi
Zheng, Duo
author_facet Yang, Heng
Chiang, Chengyao
Luo, Qinhong
Chen, Chunlan
Huang, Junrong
Zhu, Lizhi
Zheng, Duo
author_sort Yang, Heng
collection PubMed
description N6-methyladenosine (m6A) is the most abundant internal chemical modification of eukaryotic mRNA and plays diverse roles in gene regulation. The m6A modification plays a significant role in numerous cancer types, including kidney, stomach, lung, bladder tumors, and melanoma, through varied mechanisms. As direct m6A readers, the YT521-B homology domain family proteins (YTHDFs) play a key role in tumor transcription, translation, protein synthesis, tumor stemness, epithelial–mesenchymal transition (EMT), immune escape, and chemotherapy resistance. An in-depth understanding of the molecular mechanism of YTHDFs is expected to provide new strategies for tumor treatment. In this review, we provide a systematic description of YTHDF protein structure and its function in tumor progression.
format Online
Article
Text
id pubmed-9395638
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-93956382022-08-24 YT521-B homology domain family proteins as N6-methyladenosine readers in tumors Yang, Heng Chiang, Chengyao Luo, Qinhong Chen, Chunlan Huang, Junrong Zhu, Lizhi Zheng, Duo Front Genet Genetics N6-methyladenosine (m6A) is the most abundant internal chemical modification of eukaryotic mRNA and plays diverse roles in gene regulation. The m6A modification plays a significant role in numerous cancer types, including kidney, stomach, lung, bladder tumors, and melanoma, through varied mechanisms. As direct m6A readers, the YT521-B homology domain family proteins (YTHDFs) play a key role in tumor transcription, translation, protein synthesis, tumor stemness, epithelial–mesenchymal transition (EMT), immune escape, and chemotherapy resistance. An in-depth understanding of the molecular mechanism of YTHDFs is expected to provide new strategies for tumor treatment. In this review, we provide a systematic description of YTHDF protein structure and its function in tumor progression. Frontiers Media S.A. 2022-08-09 /pmc/articles/PMC9395638/ /pubmed/36017491 http://dx.doi.org/10.3389/fgene.2022.934223 Text en Copyright © 2022 Yang, Chiang, Luo, Chen, Huang, Zhu and Zheng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Yang, Heng
Chiang, Chengyao
Luo, Qinhong
Chen, Chunlan
Huang, Junrong
Zhu, Lizhi
Zheng, Duo
YT521-B homology domain family proteins as N6-methyladenosine readers in tumors
title YT521-B homology domain family proteins as N6-methyladenosine readers in tumors
title_full YT521-B homology domain family proteins as N6-methyladenosine readers in tumors
title_fullStr YT521-B homology domain family proteins as N6-methyladenosine readers in tumors
title_full_unstemmed YT521-B homology domain family proteins as N6-methyladenosine readers in tumors
title_short YT521-B homology domain family proteins as N6-methyladenosine readers in tumors
title_sort yt521-b homology domain family proteins as n6-methyladenosine readers in tumors
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395638/
https://www.ncbi.nlm.nih.gov/pubmed/36017491
http://dx.doi.org/10.3389/fgene.2022.934223
work_keys_str_mv AT yangheng yt521bhomologydomainfamilyproteinsasn6methyladenosinereadersintumors
AT chiangchengyao yt521bhomologydomainfamilyproteinsasn6methyladenosinereadersintumors
AT luoqinhong yt521bhomologydomainfamilyproteinsasn6methyladenosinereadersintumors
AT chenchunlan yt521bhomologydomainfamilyproteinsasn6methyladenosinereadersintumors
AT huangjunrong yt521bhomologydomainfamilyproteinsasn6methyladenosinereadersintumors
AT zhulizhi yt521bhomologydomainfamilyproteinsasn6methyladenosinereadersintumors
AT zhengduo yt521bhomologydomainfamilyproteinsasn6methyladenosinereadersintumors

Ejemplares similares