Cargando…
When liquid-liquid phase separation meets viral infections
Eukaryotic cells have both membranous and membraneless organelles. While the formation mechanism of membranous organelles is well understood, the formation mechanism of membraneless organelles remains unknown. Many biomolecules in the cytoplasm transition from the liquid phase to the agglutinated ph...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395683/ https://www.ncbi.nlm.nih.gov/pubmed/36016945 http://dx.doi.org/10.3389/fimmu.2022.985622 |
_version_ | 1784771754586013696 |
---|---|
author | Wei, Wenqiang Bai, Lu Yan, Bing Meng, Weiquan Wang, Hongju Zhai, Jingbo Si, Fusheng Zheng, Chunfu |
author_facet | Wei, Wenqiang Bai, Lu Yan, Bing Meng, Weiquan Wang, Hongju Zhai, Jingbo Si, Fusheng Zheng, Chunfu |
author_sort | Wei, Wenqiang |
collection | PubMed |
description | Eukaryotic cells have both membranous and membraneless organelles. While the formation mechanism of membranous organelles is well understood, the formation mechanism of membraneless organelles remains unknown. Many biomolecules in the cytoplasm transition from the liquid phase to the agglutinated phase are known as liquid-liquid phase separation (LLPS). The biomolecular agglomerates’ physical properties enable them to function as dynamic compartments that respond to external pressures and stimuli. Scientists have gradually recognized the importance of phase separation during viral infections. LLPS provides a powerful new framework for understanding the viral life cycle from viral replication to evasion of host immune surveillance. As a result, this review focuses on the progress of LLPS research in viral infection and immune regulation to provide clues for antiviral therapeutic strategies. |
format | Online Article Text |
id | pubmed-9395683 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93956832022-08-24 When liquid-liquid phase separation meets viral infections Wei, Wenqiang Bai, Lu Yan, Bing Meng, Weiquan Wang, Hongju Zhai, Jingbo Si, Fusheng Zheng, Chunfu Front Immunol Immunology Eukaryotic cells have both membranous and membraneless organelles. While the formation mechanism of membranous organelles is well understood, the formation mechanism of membraneless organelles remains unknown. Many biomolecules in the cytoplasm transition from the liquid phase to the agglutinated phase are known as liquid-liquid phase separation (LLPS). The biomolecular agglomerates’ physical properties enable them to function as dynamic compartments that respond to external pressures and stimuli. Scientists have gradually recognized the importance of phase separation during viral infections. LLPS provides a powerful new framework for understanding the viral life cycle from viral replication to evasion of host immune surveillance. As a result, this review focuses on the progress of LLPS research in viral infection and immune regulation to provide clues for antiviral therapeutic strategies. Frontiers Media S.A. 2022-08-09 /pmc/articles/PMC9395683/ /pubmed/36016945 http://dx.doi.org/10.3389/fimmu.2022.985622 Text en Copyright © 2022 Wei, Bai, Yan, Meng, Wang, Zhai, Si and Zheng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Wei, Wenqiang Bai, Lu Yan, Bing Meng, Weiquan Wang, Hongju Zhai, Jingbo Si, Fusheng Zheng, Chunfu When liquid-liquid phase separation meets viral infections |
title | When liquid-liquid phase separation meets viral infections |
title_full | When liquid-liquid phase separation meets viral infections |
title_fullStr | When liquid-liquid phase separation meets viral infections |
title_full_unstemmed | When liquid-liquid phase separation meets viral infections |
title_short | When liquid-liquid phase separation meets viral infections |
title_sort | when liquid-liquid phase separation meets viral infections |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395683/ https://www.ncbi.nlm.nih.gov/pubmed/36016945 http://dx.doi.org/10.3389/fimmu.2022.985622 |
work_keys_str_mv | AT weiwenqiang whenliquidliquidphaseseparationmeetsviralinfections AT bailu whenliquidliquidphaseseparationmeetsviralinfections AT yanbing whenliquidliquidphaseseparationmeetsviralinfections AT mengweiquan whenliquidliquidphaseseparationmeetsviralinfections AT wanghongju whenliquidliquidphaseseparationmeetsviralinfections AT zhaijingbo whenliquidliquidphaseseparationmeetsviralinfections AT sifusheng whenliquidliquidphaseseparationmeetsviralinfections AT zhengchunfu whenliquidliquidphaseseparationmeetsviralinfections |