Cargando…

Piglets' acute responses to procaine-based local anesthetic injection and surgical castration: Effects of two volumes of anesthetic

Surgical castration of piglets is painful, but practiced routinely in commercial pig production. Procaine-based local anesthetics are used to mitigate piglet pain during castration in some countries. Yet, effects of the volume of anesthetic injected remain under-studied. The volume of drug administe...

Descripción completa

Detalles Bibliográficos
Autores principales: Coutant, Mathilde, Malmkvist, Jens, Kaiser, Marianne, Foldager, Leslie, Herskin, Mette S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395716/
https://www.ncbi.nlm.nih.gov/pubmed/36017329
http://dx.doi.org/10.3389/fpain.2022.943138
_version_ 1784771765082259456
author Coutant, Mathilde
Malmkvist, Jens
Kaiser, Marianne
Foldager, Leslie
Herskin, Mette S.
author_facet Coutant, Mathilde
Malmkvist, Jens
Kaiser, Marianne
Foldager, Leslie
Herskin, Mette S.
author_sort Coutant, Mathilde
collection PubMed
description Surgical castration of piglets is painful, but practiced routinely in commercial pig production. Procaine-based local anesthetics are used to mitigate piglet pain during castration in some countries. Yet, effects of the volume of anesthetic injected remain under-studied. The volume of drug administered may modulate the pain mitigating effect via variation in intra-testicular pressure at injection, potentially leading to pain or discomfort, as well as variation in the dose of active ingredient administered. The present study investigated the effects of injection with two volumes of a procaine-based local anesthetic, 0.3 vs. 0.5 mL per testis, on acute responses of 3–4 day old piglets. A total of 290 piglets were divided into 5 treatment groups: castration without anesthesia, castration after intra-testicular injection of 0.5 or 0.3 mL of drug per testis, and sham handling with one or two stays in a castration bench. Acute responses to drug injection, castration and sham handling were evaluated based on quantification of intra-procedural vocalizations and foreleg movements, as well as saliva cortisol concentrations before and after castration. Regardless of the volume, injection of anesthetic as well as castration led to significantly stronger responses than sham handling. Responses to the two drug volumes did not differ significantly, and responses to castration following injection of 0.3 mL did not differ from piglets castrated without anesthesia. All treatments, including sham handling, led to a significant increase in saliva cortisol, and no difference was found between anesthesia treatments and sham handling. Overall, the results suggested that injection of 0.5 mL led to better pain mitigation at castration compared to injection of 0.3 mL, but even when the local anesthetic was used, the combined procedures of injection and castration led to intra-procedural signs of pain and stress.
format Online
Article
Text
id pubmed-9395716
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-93957162022-08-24 Piglets' acute responses to procaine-based local anesthetic injection and surgical castration: Effects of two volumes of anesthetic Coutant, Mathilde Malmkvist, Jens Kaiser, Marianne Foldager, Leslie Herskin, Mette S. Front Pain Res (Lausanne) Pain Research Surgical castration of piglets is painful, but practiced routinely in commercial pig production. Procaine-based local anesthetics are used to mitigate piglet pain during castration in some countries. Yet, effects of the volume of anesthetic injected remain under-studied. The volume of drug administered may modulate the pain mitigating effect via variation in intra-testicular pressure at injection, potentially leading to pain or discomfort, as well as variation in the dose of active ingredient administered. The present study investigated the effects of injection with two volumes of a procaine-based local anesthetic, 0.3 vs. 0.5 mL per testis, on acute responses of 3–4 day old piglets. A total of 290 piglets were divided into 5 treatment groups: castration without anesthesia, castration after intra-testicular injection of 0.5 or 0.3 mL of drug per testis, and sham handling with one or two stays in a castration bench. Acute responses to drug injection, castration and sham handling were evaluated based on quantification of intra-procedural vocalizations and foreleg movements, as well as saliva cortisol concentrations before and after castration. Regardless of the volume, injection of anesthetic as well as castration led to significantly stronger responses than sham handling. Responses to the two drug volumes did not differ significantly, and responses to castration following injection of 0.3 mL did not differ from piglets castrated without anesthesia. All treatments, including sham handling, led to a significant increase in saliva cortisol, and no difference was found between anesthesia treatments and sham handling. Overall, the results suggested that injection of 0.5 mL led to better pain mitigation at castration compared to injection of 0.3 mL, but even when the local anesthetic was used, the combined procedures of injection and castration led to intra-procedural signs of pain and stress. Frontiers Media S.A. 2022-08-09 /pmc/articles/PMC9395716/ /pubmed/36017329 http://dx.doi.org/10.3389/fpain.2022.943138 Text en Copyright © 2022 Coutant, Malmkvist, Kaiser, Foldager and Herskin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pain Research
Coutant, Mathilde
Malmkvist, Jens
Kaiser, Marianne
Foldager, Leslie
Herskin, Mette S.
Piglets' acute responses to procaine-based local anesthetic injection and surgical castration: Effects of two volumes of anesthetic
title Piglets' acute responses to procaine-based local anesthetic injection and surgical castration: Effects of two volumes of anesthetic
title_full Piglets' acute responses to procaine-based local anesthetic injection and surgical castration: Effects of two volumes of anesthetic
title_fullStr Piglets' acute responses to procaine-based local anesthetic injection and surgical castration: Effects of two volumes of anesthetic
title_full_unstemmed Piglets' acute responses to procaine-based local anesthetic injection and surgical castration: Effects of two volumes of anesthetic
title_short Piglets' acute responses to procaine-based local anesthetic injection and surgical castration: Effects of two volumes of anesthetic
title_sort piglets' acute responses to procaine-based local anesthetic injection and surgical castration: effects of two volumes of anesthetic
topic Pain Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395716/
https://www.ncbi.nlm.nih.gov/pubmed/36017329
http://dx.doi.org/10.3389/fpain.2022.943138
work_keys_str_mv AT coutantmathilde pigletsacuteresponsestoprocainebasedlocalanestheticinjectionandsurgicalcastrationeffectsoftwovolumesofanesthetic
AT malmkvistjens pigletsacuteresponsestoprocainebasedlocalanestheticinjectionandsurgicalcastrationeffectsoftwovolumesofanesthetic
AT kaisermarianne pigletsacuteresponsestoprocainebasedlocalanestheticinjectionandsurgicalcastrationeffectsoftwovolumesofanesthetic
AT foldagerleslie pigletsacuteresponsestoprocainebasedlocalanestheticinjectionandsurgicalcastrationeffectsoftwovolumesofanesthetic
AT herskinmettes pigletsacuteresponsestoprocainebasedlocalanestheticinjectionandsurgicalcastrationeffectsoftwovolumesofanesthetic