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Establishing the Association Between Osteoporosis and Peptic Ulcer Disease: A Systematic Review

Osteoporosis is one of the most common metabolic bone diseases. Many studies were conducted to find the association between peptic ulcer disease (PUD), Helicobacter pylori infection, proton-pump inhibitor (PPI) use, and increased risk for fracture, but results remain ambiguous. We performed this sys...

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Autores principales: Teresa Selvin, Sneha, Thomas, Sonu, Bikeyeva, Viktoriya, Abdullah, Ahmed, Radivojevic, Aleksandra, Abu Jad, Anas A, Ravanavena, Anvesh, Ravindra, Chetna, Igweonu-Nwakile, Emmanuelar O, Ali, Safina, Paul, Salomi, Yakkali, Shreyas, Balani, Prachi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395758/
https://www.ncbi.nlm.nih.gov/pubmed/36039217
http://dx.doi.org/10.7759/cureus.27188
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author Teresa Selvin, Sneha
Thomas, Sonu
Bikeyeva, Viktoriya
Abdullah, Ahmed
Radivojevic, Aleksandra
Abu Jad, Anas A
Ravanavena, Anvesh
Ravindra, Chetna
Igweonu-Nwakile, Emmanuelar O
Ali, Safina
Paul, Salomi
Yakkali, Shreyas
Balani, Prachi
author_facet Teresa Selvin, Sneha
Thomas, Sonu
Bikeyeva, Viktoriya
Abdullah, Ahmed
Radivojevic, Aleksandra
Abu Jad, Anas A
Ravanavena, Anvesh
Ravindra, Chetna
Igweonu-Nwakile, Emmanuelar O
Ali, Safina
Paul, Salomi
Yakkali, Shreyas
Balani, Prachi
author_sort Teresa Selvin, Sneha
collection PubMed
description Osteoporosis is one of the most common metabolic bone diseases. Many studies were conducted to find the association between peptic ulcer disease (PUD), Helicobacter pylori infection, proton-pump inhibitor (PPI) use, and increased risk for fracture, but results remain ambiguous. We performed this systematic review to understand the association between PUD and osteoporosis. We comprehensively searched relevant articles on April 19, 2022, by exploring different databases including PubMed, PubMed Central (PMC), and Medline using relevant keywords. After applying inclusion and exclusion criteria and undergoing quality assessment, we retained 25 studies published in and after 2015. For our systematic review, we included a total of 5,600,636 participants. The studies included in our review demonstrated a significant association between PUD, H. pylori infection, and the risk of osteoporosis. Long-term PPI use was also found to be a risk factor for osteoporosis. Malabsorption of nutrients, increase in inflammatory cytokines, and alterations in hormone status were found to be the notable factors behind the association. Early management of H. pylori infection and cautious use of long-term PPIs may protect against osteoporosis. Further randomized controlled trials (RCTs) are necessary to establish a causal relationship.
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spelling pubmed-93957582022-08-28 Establishing the Association Between Osteoporosis and Peptic Ulcer Disease: A Systematic Review Teresa Selvin, Sneha Thomas, Sonu Bikeyeva, Viktoriya Abdullah, Ahmed Radivojevic, Aleksandra Abu Jad, Anas A Ravanavena, Anvesh Ravindra, Chetna Igweonu-Nwakile, Emmanuelar O Ali, Safina Paul, Salomi Yakkali, Shreyas Balani, Prachi Cureus Internal Medicine Osteoporosis is one of the most common metabolic bone diseases. Many studies were conducted to find the association between peptic ulcer disease (PUD), Helicobacter pylori infection, proton-pump inhibitor (PPI) use, and increased risk for fracture, but results remain ambiguous. We performed this systematic review to understand the association between PUD and osteoporosis. We comprehensively searched relevant articles on April 19, 2022, by exploring different databases including PubMed, PubMed Central (PMC), and Medline using relevant keywords. After applying inclusion and exclusion criteria and undergoing quality assessment, we retained 25 studies published in and after 2015. For our systematic review, we included a total of 5,600,636 participants. The studies included in our review demonstrated a significant association between PUD, H. pylori infection, and the risk of osteoporosis. Long-term PPI use was also found to be a risk factor for osteoporosis. Malabsorption of nutrients, increase in inflammatory cytokines, and alterations in hormone status were found to be the notable factors behind the association. Early management of H. pylori infection and cautious use of long-term PPIs may protect against osteoporosis. Further randomized controlled trials (RCTs) are necessary to establish a causal relationship. Cureus 2022-07-23 /pmc/articles/PMC9395758/ /pubmed/36039217 http://dx.doi.org/10.7759/cureus.27188 Text en Copyright © 2022, Teresa Selvin et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Teresa Selvin, Sneha
Thomas, Sonu
Bikeyeva, Viktoriya
Abdullah, Ahmed
Radivojevic, Aleksandra
Abu Jad, Anas A
Ravanavena, Anvesh
Ravindra, Chetna
Igweonu-Nwakile, Emmanuelar O
Ali, Safina
Paul, Salomi
Yakkali, Shreyas
Balani, Prachi
Establishing the Association Between Osteoporosis and Peptic Ulcer Disease: A Systematic Review
title Establishing the Association Between Osteoporosis and Peptic Ulcer Disease: A Systematic Review
title_full Establishing the Association Between Osteoporosis and Peptic Ulcer Disease: A Systematic Review
title_fullStr Establishing the Association Between Osteoporosis and Peptic Ulcer Disease: A Systematic Review
title_full_unstemmed Establishing the Association Between Osteoporosis and Peptic Ulcer Disease: A Systematic Review
title_short Establishing the Association Between Osteoporosis and Peptic Ulcer Disease: A Systematic Review
title_sort establishing the association between osteoporosis and peptic ulcer disease: a systematic review
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395758/
https://www.ncbi.nlm.nih.gov/pubmed/36039217
http://dx.doi.org/10.7759/cureus.27188
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