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Establishing the Association Between Osteoporosis and Peptic Ulcer Disease: A Systematic Review
Osteoporosis is one of the most common metabolic bone diseases. Many studies were conducted to find the association between peptic ulcer disease (PUD), Helicobacter pylori infection, proton-pump inhibitor (PPI) use, and increased risk for fracture, but results remain ambiguous. We performed this sys...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395758/ https://www.ncbi.nlm.nih.gov/pubmed/36039217 http://dx.doi.org/10.7759/cureus.27188 |
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author | Teresa Selvin, Sneha Thomas, Sonu Bikeyeva, Viktoriya Abdullah, Ahmed Radivojevic, Aleksandra Abu Jad, Anas A Ravanavena, Anvesh Ravindra, Chetna Igweonu-Nwakile, Emmanuelar O Ali, Safina Paul, Salomi Yakkali, Shreyas Balani, Prachi |
author_facet | Teresa Selvin, Sneha Thomas, Sonu Bikeyeva, Viktoriya Abdullah, Ahmed Radivojevic, Aleksandra Abu Jad, Anas A Ravanavena, Anvesh Ravindra, Chetna Igweonu-Nwakile, Emmanuelar O Ali, Safina Paul, Salomi Yakkali, Shreyas Balani, Prachi |
author_sort | Teresa Selvin, Sneha |
collection | PubMed |
description | Osteoporosis is one of the most common metabolic bone diseases. Many studies were conducted to find the association between peptic ulcer disease (PUD), Helicobacter pylori infection, proton-pump inhibitor (PPI) use, and increased risk for fracture, but results remain ambiguous. We performed this systematic review to understand the association between PUD and osteoporosis. We comprehensively searched relevant articles on April 19, 2022, by exploring different databases including PubMed, PubMed Central (PMC), and Medline using relevant keywords. After applying inclusion and exclusion criteria and undergoing quality assessment, we retained 25 studies published in and after 2015. For our systematic review, we included a total of 5,600,636 participants. The studies included in our review demonstrated a significant association between PUD, H. pylori infection, and the risk of osteoporosis. Long-term PPI use was also found to be a risk factor for osteoporosis. Malabsorption of nutrients, increase in inflammatory cytokines, and alterations in hormone status were found to be the notable factors behind the association. Early management of H. pylori infection and cautious use of long-term PPIs may protect against osteoporosis. Further randomized controlled trials (RCTs) are necessary to establish a causal relationship. |
format | Online Article Text |
id | pubmed-9395758 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-93957582022-08-28 Establishing the Association Between Osteoporosis and Peptic Ulcer Disease: A Systematic Review Teresa Selvin, Sneha Thomas, Sonu Bikeyeva, Viktoriya Abdullah, Ahmed Radivojevic, Aleksandra Abu Jad, Anas A Ravanavena, Anvesh Ravindra, Chetna Igweonu-Nwakile, Emmanuelar O Ali, Safina Paul, Salomi Yakkali, Shreyas Balani, Prachi Cureus Internal Medicine Osteoporosis is one of the most common metabolic bone diseases. Many studies were conducted to find the association between peptic ulcer disease (PUD), Helicobacter pylori infection, proton-pump inhibitor (PPI) use, and increased risk for fracture, but results remain ambiguous. We performed this systematic review to understand the association between PUD and osteoporosis. We comprehensively searched relevant articles on April 19, 2022, by exploring different databases including PubMed, PubMed Central (PMC), and Medline using relevant keywords. After applying inclusion and exclusion criteria and undergoing quality assessment, we retained 25 studies published in and after 2015. For our systematic review, we included a total of 5,600,636 participants. The studies included in our review demonstrated a significant association between PUD, H. pylori infection, and the risk of osteoporosis. Long-term PPI use was also found to be a risk factor for osteoporosis. Malabsorption of nutrients, increase in inflammatory cytokines, and alterations in hormone status were found to be the notable factors behind the association. Early management of H. pylori infection and cautious use of long-term PPIs may protect against osteoporosis. Further randomized controlled trials (RCTs) are necessary to establish a causal relationship. Cureus 2022-07-23 /pmc/articles/PMC9395758/ /pubmed/36039217 http://dx.doi.org/10.7759/cureus.27188 Text en Copyright © 2022, Teresa Selvin et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine Teresa Selvin, Sneha Thomas, Sonu Bikeyeva, Viktoriya Abdullah, Ahmed Radivojevic, Aleksandra Abu Jad, Anas A Ravanavena, Anvesh Ravindra, Chetna Igweonu-Nwakile, Emmanuelar O Ali, Safina Paul, Salomi Yakkali, Shreyas Balani, Prachi Establishing the Association Between Osteoporosis and Peptic Ulcer Disease: A Systematic Review |
title | Establishing the Association Between Osteoporosis and Peptic Ulcer Disease: A Systematic Review |
title_full | Establishing the Association Between Osteoporosis and Peptic Ulcer Disease: A Systematic Review |
title_fullStr | Establishing the Association Between Osteoporosis and Peptic Ulcer Disease: A Systematic Review |
title_full_unstemmed | Establishing the Association Between Osteoporosis and Peptic Ulcer Disease: A Systematic Review |
title_short | Establishing the Association Between Osteoporosis and Peptic Ulcer Disease: A Systematic Review |
title_sort | establishing the association between osteoporosis and peptic ulcer disease: a systematic review |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395758/ https://www.ncbi.nlm.nih.gov/pubmed/36039217 http://dx.doi.org/10.7759/cureus.27188 |
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