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A case report of primary colonic paraganglioma with lymph node metastasis

BACKGROUND: Paraganglioma is a kind of neuroendocrine tumor that originates from paraganglia outside the adrenal gland. Gastrointestinal tract paraganglioma is very rare and only four cases of paraganglioma originating in the colon have been reported. CASE PRESENTATION: We report a case of metastati...

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Autores principales: Zhu, Xinyi, Huang, Zhen, Dong, Lin, Zhao, Hong, Lu, Haizhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395918/
https://www.ncbi.nlm.nih.gov/pubmed/36017518
http://dx.doi.org/10.3389/fsurg.2022.961514
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author Zhu, Xinyi
Huang, Zhen
Dong, Lin
Zhao, Hong
Lu, Haizhen
author_facet Zhu, Xinyi
Huang, Zhen
Dong, Lin
Zhao, Hong
Lu, Haizhen
author_sort Zhu, Xinyi
collection PubMed
description BACKGROUND: Paraganglioma is a kind of neuroendocrine tumor that originates from paraganglia outside the adrenal gland. Gastrointestinal tract paraganglioma is very rare and only four cases of paraganglioma originating in the colon have been reported. CASE PRESENTATION: We report a case of metastatic paraganglioma originating in the colon, in which the differential diagnosis was established by comprehensively considering clinical information, histology, immunohistochemistry, and findings of fluorescence in situ hybridization and next generation sequencing analyses. The patient has remained well for over 14 months after the treatment. CONCLUSION: Since all paraganglioma have metastatic potential, we believe that radical surgical resection and regular follow-up are necessary. Genetic testing may be indicative of metastatic potential and prognosis. Because colonic paraganglioma is very rare, differential diagnosis is very important. Our report provides experience for the diagnosis and study of paraganglioma in rare sites.
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spelling pubmed-93959182022-08-24 A case report of primary colonic paraganglioma with lymph node metastasis Zhu, Xinyi Huang, Zhen Dong, Lin Zhao, Hong Lu, Haizhen Front Surg Surgery BACKGROUND: Paraganglioma is a kind of neuroendocrine tumor that originates from paraganglia outside the adrenal gland. Gastrointestinal tract paraganglioma is very rare and only four cases of paraganglioma originating in the colon have been reported. CASE PRESENTATION: We report a case of metastatic paraganglioma originating in the colon, in which the differential diagnosis was established by comprehensively considering clinical information, histology, immunohistochemistry, and findings of fluorescence in situ hybridization and next generation sequencing analyses. The patient has remained well for over 14 months after the treatment. CONCLUSION: Since all paraganglioma have metastatic potential, we believe that radical surgical resection and regular follow-up are necessary. Genetic testing may be indicative of metastatic potential and prognosis. Because colonic paraganglioma is very rare, differential diagnosis is very important. Our report provides experience for the diagnosis and study of paraganglioma in rare sites. Frontiers Media S.A. 2022-08-09 /pmc/articles/PMC9395918/ /pubmed/36017518 http://dx.doi.org/10.3389/fsurg.2022.961514 Text en © 2022 Zhu, Huang, Dong, Zhao and Lu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Surgery
Zhu, Xinyi
Huang, Zhen
Dong, Lin
Zhao, Hong
Lu, Haizhen
A case report of primary colonic paraganglioma with lymph node metastasis
title A case report of primary colonic paraganglioma with lymph node metastasis
title_full A case report of primary colonic paraganglioma with lymph node metastasis
title_fullStr A case report of primary colonic paraganglioma with lymph node metastasis
title_full_unstemmed A case report of primary colonic paraganglioma with lymph node metastasis
title_short A case report of primary colonic paraganglioma with lymph node metastasis
title_sort case report of primary colonic paraganglioma with lymph node metastasis
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395918/
https://www.ncbi.nlm.nih.gov/pubmed/36017518
http://dx.doi.org/10.3389/fsurg.2022.961514
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