Very severe immune thrombocytopenia following SARS-CoV-2 vaccination requiring splenectomy: a case report

BACKGROUND: Some conventional vaccines have been recognized as a cause of secondary immune thrombocytopenia (ITP). According to recent publications, mRNA vaccines are probably associated with an increased risk of ITP. CASE PRESENTATION: Our patient developed severe ITP one week after the second dose...

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Autores principales: Weiner, Marc, Rodriguez-Vigouroux, Robert, Masouridi-Levrat, Stavroula, Samii, Kaveh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395928/
https://www.ncbi.nlm.nih.gov/pubmed/35996108
http://dx.doi.org/10.1186/s12959-022-00404-z
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author Weiner, Marc
Rodriguez-Vigouroux, Robert
Masouridi-Levrat, Stavroula
Samii, Kaveh
author_facet Weiner, Marc
Rodriguez-Vigouroux, Robert
Masouridi-Levrat, Stavroula
Samii, Kaveh
author_sort Weiner, Marc
collection PubMed
description BACKGROUND: Some conventional vaccines have been recognized as a cause of secondary immune thrombocytopenia (ITP). According to recent publications, mRNA vaccines are probably associated with an increased risk of ITP. CASE PRESENTATION: Our patient developed severe ITP one week after the second dose of COVID-19 mRNA vaccine. Medical management was not effective, requiring splenectomy to obtain sustained remission. CONCLUSION: Considering the temporality and immunological hypothesis, we consider the vaccine to be the trigger of this ITP. To our knowledge, our case is, to date, the most severe case of ITP reported following SARS-CoV-2 vaccination and could help for the therapeutic management of similar patients.
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spelling pubmed-93959282022-08-23 Very severe immune thrombocytopenia following SARS-CoV-2 vaccination requiring splenectomy: a case report Weiner, Marc Rodriguez-Vigouroux, Robert Masouridi-Levrat, Stavroula Samii, Kaveh Thromb J Case Report BACKGROUND: Some conventional vaccines have been recognized as a cause of secondary immune thrombocytopenia (ITP). According to recent publications, mRNA vaccines are probably associated with an increased risk of ITP. CASE PRESENTATION: Our patient developed severe ITP one week after the second dose of COVID-19 mRNA vaccine. Medical management was not effective, requiring splenectomy to obtain sustained remission. CONCLUSION: Considering the temporality and immunological hypothesis, we consider the vaccine to be the trigger of this ITP. To our knowledge, our case is, to date, the most severe case of ITP reported following SARS-CoV-2 vaccination and could help for the therapeutic management of similar patients. BioMed Central 2022-08-23 /pmc/articles/PMC9395928/ /pubmed/35996108 http://dx.doi.org/10.1186/s12959-022-00404-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Weiner, Marc
Rodriguez-Vigouroux, Robert
Masouridi-Levrat, Stavroula
Samii, Kaveh
Very severe immune thrombocytopenia following SARS-CoV-2 vaccination requiring splenectomy: a case report
title Very severe immune thrombocytopenia following SARS-CoV-2 vaccination requiring splenectomy: a case report
title_full Very severe immune thrombocytopenia following SARS-CoV-2 vaccination requiring splenectomy: a case report
title_fullStr Very severe immune thrombocytopenia following SARS-CoV-2 vaccination requiring splenectomy: a case report
title_full_unstemmed Very severe immune thrombocytopenia following SARS-CoV-2 vaccination requiring splenectomy: a case report
title_short Very severe immune thrombocytopenia following SARS-CoV-2 vaccination requiring splenectomy: a case report
title_sort very severe immune thrombocytopenia following sars-cov-2 vaccination requiring splenectomy: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395928/
https://www.ncbi.nlm.nih.gov/pubmed/35996108
http://dx.doi.org/10.1186/s12959-022-00404-z
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