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Can Laparoscopic Cystectomy Improve Pregnancy Outcomes in Endometrioma? A Prospective Clinical Trial Study

BACKGROUND: The purpose of this prospective study was to compare the ovarian response and pregnancy outcomes in the infertile women with endometrioma undergoing assisted reproductive technologies (ART) in two groups, who were underwent laparoscopic cystectomy and received gonadotropin releasing horm...

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Autores principales: Hosseinimousa, Sedigheh, Safdarian, Leili, Aleyasin, Ashraf, Aghahosseini, Marzieh, Marzieh, Talebian, Talebian, Marzieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royan Institute 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396010/
https://www.ncbi.nlm.nih.gov/pubmed/36029058
http://dx.doi.org/10.22074/IJFS.2021.521378.1066
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author Hosseinimousa, Sedigheh
Safdarian, Leili
Aleyasin, Ashraf
Aghahosseini, Marzieh
Marzieh, Talebian
Talebian, Marzieh
author_facet Hosseinimousa, Sedigheh
Safdarian, Leili
Aleyasin, Ashraf
Aghahosseini, Marzieh
Marzieh, Talebian
Talebian, Marzieh
author_sort Hosseinimousa, Sedigheh
collection PubMed
description BACKGROUND: The purpose of this prospective study was to compare the ovarian response and pregnancy outcomes in the infertile women with endometrioma undergoing assisted reproductive technologies (ART) in two groups, who were underwent laparoscopic cystectomy and received gonadotropin releasing hormone-agonist (GnRH-agonist) and who only received GnRH-agonist without any surgery. MATERIALS AND METHODS: In this prospective clinical trial study, 79 infertile women with asymptomatic endometriomas cyst (2-6 cm) were enrolled and randomly assigned to two groups. First group underwent laparoscopic cystectomy and received GnRH-agonist. Second group only received GnRH-agonist without any surgery. Following ovulation induction, all patients underwent intracytoplasmic sperm injection (ICSI). Different parameters such as the number of retrieved oocytes and embryos; were made our outcomes that analyzed using SPSS. RESULTS: The pregnancy rate, chemical and clinical, and live birth rate were higher in the combined group, although these differences were not statistically significant (48.48% vs. 30.8%, P=0.12, 36.36% vs. 25.6%, P=0.32, 36.36% vs. 23.1%, P=0.29). The number of injections, antral follicles, retrieved oocytes, mature oocytes, total embryos, transferred embryos and duration of stimulation were similar in two groups. CONCLUSION: Laparoscopic cystectomy followed by receiving GnRH-agonist improves pregnancy outcomes in endometrioma prior to treatment with ART (registration number: IRCT201106116689N2).
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spelling pubmed-93960102022-08-28 Can Laparoscopic Cystectomy Improve Pregnancy Outcomes in Endometrioma? A Prospective Clinical Trial Study Hosseinimousa, Sedigheh Safdarian, Leili Aleyasin, Ashraf Aghahosseini, Marzieh Marzieh, Talebian Talebian, Marzieh Int J Fertil Steril Original Article BACKGROUND: The purpose of this prospective study was to compare the ovarian response and pregnancy outcomes in the infertile women with endometrioma undergoing assisted reproductive technologies (ART) in two groups, who were underwent laparoscopic cystectomy and received gonadotropin releasing hormone-agonist (GnRH-agonist) and who only received GnRH-agonist without any surgery. MATERIALS AND METHODS: In this prospective clinical trial study, 79 infertile women with asymptomatic endometriomas cyst (2-6 cm) were enrolled and randomly assigned to two groups. First group underwent laparoscopic cystectomy and received GnRH-agonist. Second group only received GnRH-agonist without any surgery. Following ovulation induction, all patients underwent intracytoplasmic sperm injection (ICSI). Different parameters such as the number of retrieved oocytes and embryos; were made our outcomes that analyzed using SPSS. RESULTS: The pregnancy rate, chemical and clinical, and live birth rate were higher in the combined group, although these differences were not statistically significant (48.48% vs. 30.8%, P=0.12, 36.36% vs. 25.6%, P=0.32, 36.36% vs. 23.1%, P=0.29). The number of injections, antral follicles, retrieved oocytes, mature oocytes, total embryos, transferred embryos and duration of stimulation were similar in two groups. CONCLUSION: Laparoscopic cystectomy followed by receiving GnRH-agonist improves pregnancy outcomes in endometrioma prior to treatment with ART (registration number: IRCT201106116689N2). Royan Institute 2022 2022-08-21 /pmc/articles/PMC9396010/ /pubmed/36029058 http://dx.doi.org/10.22074/IJFS.2021.521378.1066 Text en Any use, distribution, reproduction or abstract of this publication in any medium, with the exception of commercial purposes, is permitted provided the original work is properly cited. https://creativecommons.org/licenses/by-nc/3.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial 3.0 (CC BY-NC 3.0) License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Hosseinimousa, Sedigheh
Safdarian, Leili
Aleyasin, Ashraf
Aghahosseini, Marzieh
Marzieh, Talebian
Talebian, Marzieh
Can Laparoscopic Cystectomy Improve Pregnancy Outcomes in Endometrioma? A Prospective Clinical Trial Study
title Can Laparoscopic Cystectomy Improve Pregnancy Outcomes in Endometrioma? A Prospective Clinical Trial Study
title_full Can Laparoscopic Cystectomy Improve Pregnancy Outcomes in Endometrioma? A Prospective Clinical Trial Study
title_fullStr Can Laparoscopic Cystectomy Improve Pregnancy Outcomes in Endometrioma? A Prospective Clinical Trial Study
title_full_unstemmed Can Laparoscopic Cystectomy Improve Pregnancy Outcomes in Endometrioma? A Prospective Clinical Trial Study
title_short Can Laparoscopic Cystectomy Improve Pregnancy Outcomes in Endometrioma? A Prospective Clinical Trial Study
title_sort can laparoscopic cystectomy improve pregnancy outcomes in endometrioma? a prospective clinical trial study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396010/
https://www.ncbi.nlm.nih.gov/pubmed/36029058
http://dx.doi.org/10.22074/IJFS.2021.521378.1066
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