Phosphate position is key in mediating transmembrane ion channel TMEM16A–phosphatidylinositol 4,5-bisphosphate interaction

TransMEMbrane 16A (TMEM16A) is a Ca(2+)-activated Cl(−) channel that plays critical roles in regulating diverse physiologic processes, including vascular tone, sensory signal transduction, and mucosal secretion. In addition to Ca(2+), TMEM16A activation requires the membrane lipid phosphatidylinosit...

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Detalles Bibliográficos
Autores principales: Tembo, Maiwase, Bainbridge, Rachel E., Lara-Santos, Crystal, Komondor, Kayla M., Daskivich, Grant J., Durrant, Jacob D., Rosenbaum, Joel C., Carlson, Anne E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396059/
https://www.ncbi.nlm.nih.gov/pubmed/35843309
http://dx.doi.org/10.1016/j.jbc.2022.102264

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