Morbidity and mortality in small for gestational age very preterm infants in a middle-income country

OBJECTIVE: To evaluate the impact of small for gestational age (SGA) on outcomes of very preterm infants at Groote Schuur Hospital (GSH), Cape Town, South Africa. STUDY DESIGN: Data were obtained from the Vermont Oxford Network (VON) GSH database from 2012 to 2018. The study is a secondary analysis...

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Autores principales: Mangiza, Marcia, Ehret, Danielle E. Y., Edwards, Erika M., Rhoda, Natasha, Tooke, Lloyd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396138/
https://www.ncbi.nlm.nih.gov/pubmed/36016879
http://dx.doi.org/10.3389/fped.2022.915796
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author Mangiza, Marcia
Ehret, Danielle E. Y.
Edwards, Erika M.
Rhoda, Natasha
Tooke, Lloyd
author_facet Mangiza, Marcia
Ehret, Danielle E. Y.
Edwards, Erika M.
Rhoda, Natasha
Tooke, Lloyd
author_sort Mangiza, Marcia
collection PubMed
description OBJECTIVE: To evaluate the impact of small for gestational age (SGA) on outcomes of very preterm infants at Groote Schuur Hospital (GSH), Cape Town, South Africa. STUDY DESIGN: Data were obtained from the Vermont Oxford Network (VON) GSH database from 2012 to 2018. The study is a secondary analysis of prospectively collected observational data. Fenton growth charts were used to define SGA as birth weight < 10th centile for gestational age. RESULTS: Mortality [28.9% vs. 18.5%, adjusted risk ratio (aRR) 2.1, 95% confidence interval (CI) 1.6–2.7], bronchopulmonary dysplasia (BPD; 14% vs. 4.5%, aRR 3.7, 95% CI 2.3–6.1), and late-onset sepsis (LOS; 16.7% vs. 9.6%, aRR 2.3, 95% CI 1.6–3.3) were higher in the SGA than in the non-SGA group. CONCLUSION: Small for gestational age infants have a higher risk of mortality and morbidity among very preterm infants at GSH. This may be useful for counseling and perinatal management.
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spelling pubmed-93961382022-08-24 Morbidity and mortality in small for gestational age very preterm infants in a middle-income country Mangiza, Marcia Ehret, Danielle E. Y. Edwards, Erika M. Rhoda, Natasha Tooke, Lloyd Front Pediatr Pediatrics OBJECTIVE: To evaluate the impact of small for gestational age (SGA) on outcomes of very preterm infants at Groote Schuur Hospital (GSH), Cape Town, South Africa. STUDY DESIGN: Data were obtained from the Vermont Oxford Network (VON) GSH database from 2012 to 2018. The study is a secondary analysis of prospectively collected observational data. Fenton growth charts were used to define SGA as birth weight < 10th centile for gestational age. RESULTS: Mortality [28.9% vs. 18.5%, adjusted risk ratio (aRR) 2.1, 95% confidence interval (CI) 1.6–2.7], bronchopulmonary dysplasia (BPD; 14% vs. 4.5%, aRR 3.7, 95% CI 2.3–6.1), and late-onset sepsis (LOS; 16.7% vs. 9.6%, aRR 2.3, 95% CI 1.6–3.3) were higher in the SGA than in the non-SGA group. CONCLUSION: Small for gestational age infants have a higher risk of mortality and morbidity among very preterm infants at GSH. This may be useful for counseling and perinatal management. Frontiers Media S.A. 2022-08-09 /pmc/articles/PMC9396138/ /pubmed/36016879 http://dx.doi.org/10.3389/fped.2022.915796 Text en Copyright © 2022 Mangiza, Ehret, Edwards, Rhoda and Tooke. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Mangiza, Marcia
Ehret, Danielle E. Y.
Edwards, Erika M.
Rhoda, Natasha
Tooke, Lloyd
Morbidity and mortality in small for gestational age very preterm infants in a middle-income country
title Morbidity and mortality in small for gestational age very preterm infants in a middle-income country
title_full Morbidity and mortality in small for gestational age very preterm infants in a middle-income country
title_fullStr Morbidity and mortality in small for gestational age very preterm infants in a middle-income country
title_full_unstemmed Morbidity and mortality in small for gestational age very preterm infants in a middle-income country
title_short Morbidity and mortality in small for gestational age very preterm infants in a middle-income country
title_sort morbidity and mortality in small for gestational age very preterm infants in a middle-income country
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396138/
https://www.ncbi.nlm.nih.gov/pubmed/36016879
http://dx.doi.org/10.3389/fped.2022.915796
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