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Multiple diagnostic methods for mucormycosis: A retrospective case series
BACKGROUND: Mucormycosis is a rare invasive fungal disease with high mortality. Early diagnosis and targeted drugs are crucial to improving clinical outcomes. METHODS: We searched the electronic hospital database of the First Affiliated Hospital of Zhejiang University School of Medicine for adult pa...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396201/ https://www.ncbi.nlm.nih.gov/pubmed/35792018 http://dx.doi.org/10.1002/jcla.24588 |
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author | Wang, JiaXin Wang, YaoMin Han, Fei Chen, JiangHua |
author_facet | Wang, JiaXin Wang, YaoMin Han, Fei Chen, JiangHua |
author_sort | Wang, JiaXin |
collection | PubMed |
description | BACKGROUND: Mucormycosis is a rare invasive fungal disease with high mortality. Early diagnosis and targeted drugs are crucial to improving clinical outcomes. METHODS: We searched the electronic hospital database of the First Affiliated Hospital of Zhejiang University School of Medicine for adult patients with mucormycosis between 2000 and 2021. Demographic, clinical, treatment, and outcome data were collected and compared with the data in the relevant literature. RESULTS: Eleven cases of mucormycosis—four of multisite infection, one of skin infection, five of lung infection, and one of gastrointestinal infection—were found and analyzed. The patients were diagnosed mainly based on pathological and histological findings, and three patients had metagenomic next‐generation sequencing findings. Delayed diagnosis (i.e., diagnosis >7 days after patient admission or >30 days after onset of symptoms) results in poor prognosis compared with early diagnosis. CONCLUSIONS: Improving awareness and shortening diagnosis time may improve the prognosis of mucormycosis. If mucormycosis is suspected, appropriate samples should be collected as soon as possible and submitted for biopsy, culture, or mNGS to confirm the diagnosis. |
format | Online Article Text |
id | pubmed-9396201 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93962012022-08-24 Multiple diagnostic methods for mucormycosis: A retrospective case series Wang, JiaXin Wang, YaoMin Han, Fei Chen, JiangHua J Clin Lab Anal Research Articles BACKGROUND: Mucormycosis is a rare invasive fungal disease with high mortality. Early diagnosis and targeted drugs are crucial to improving clinical outcomes. METHODS: We searched the electronic hospital database of the First Affiliated Hospital of Zhejiang University School of Medicine for adult patients with mucormycosis between 2000 and 2021. Demographic, clinical, treatment, and outcome data were collected and compared with the data in the relevant literature. RESULTS: Eleven cases of mucormycosis—four of multisite infection, one of skin infection, five of lung infection, and one of gastrointestinal infection—were found and analyzed. The patients were diagnosed mainly based on pathological and histological findings, and three patients had metagenomic next‐generation sequencing findings. Delayed diagnosis (i.e., diagnosis >7 days after patient admission or >30 days after onset of symptoms) results in poor prognosis compared with early diagnosis. CONCLUSIONS: Improving awareness and shortening diagnosis time may improve the prognosis of mucormycosis. If mucormycosis is suspected, appropriate samples should be collected as soon as possible and submitted for biopsy, culture, or mNGS to confirm the diagnosis. John Wiley and Sons Inc. 2022-07-06 /pmc/articles/PMC9396201/ /pubmed/35792018 http://dx.doi.org/10.1002/jcla.24588 Text en © 2022 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Articles Wang, JiaXin Wang, YaoMin Han, Fei Chen, JiangHua Multiple diagnostic methods for mucormycosis: A retrospective case series |
title | Multiple diagnostic methods for mucormycosis: A retrospective case series |
title_full | Multiple diagnostic methods for mucormycosis: A retrospective case series |
title_fullStr | Multiple diagnostic methods for mucormycosis: A retrospective case series |
title_full_unstemmed | Multiple diagnostic methods for mucormycosis: A retrospective case series |
title_short | Multiple diagnostic methods for mucormycosis: A retrospective case series |
title_sort | multiple diagnostic methods for mucormycosis: a retrospective case series |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396201/ https://www.ncbi.nlm.nih.gov/pubmed/35792018 http://dx.doi.org/10.1002/jcla.24588 |
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