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Modulation of cortical resting state functional connectivity during a visuospatial attention task in Parkinson's disease

Visual dysfunction is a recognized early symptom of Parkinson's disease (PD) that partly scales motor symptoms, yet its background is heterogeneous. With additional deficits in visuospatial attention, the two systems are hard to disentangle and it is not known whether impaired functional connec...

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Autores principales: Veréb, Dániel, Kovács, Márton Attila, Antal, Szabolcs, Kocsis, Krisztián, Szabó, Nikoletta, Kincses, Bálint, Bozsik, Bence, Faragó, Péter, Tóth, Eszter, Király, András, Klivényi, Péter, Zádori, Dénes, Kincses, Zsigmond Tamás
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396258/
https://www.ncbi.nlm.nih.gov/pubmed/36016543
http://dx.doi.org/10.3389/fneur.2022.927481
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author Veréb, Dániel
Kovács, Márton Attila
Antal, Szabolcs
Kocsis, Krisztián
Szabó, Nikoletta
Kincses, Bálint
Bozsik, Bence
Faragó, Péter
Tóth, Eszter
Király, András
Klivényi, Péter
Zádori, Dénes
Kincses, Zsigmond Tamás
author_facet Veréb, Dániel
Kovács, Márton Attila
Antal, Szabolcs
Kocsis, Krisztián
Szabó, Nikoletta
Kincses, Bálint
Bozsik, Bence
Faragó, Péter
Tóth, Eszter
Király, András
Klivényi, Péter
Zádori, Dénes
Kincses, Zsigmond Tamás
author_sort Veréb, Dániel
collection PubMed
description Visual dysfunction is a recognized early symptom of Parkinson's disease (PD) that partly scales motor symptoms, yet its background is heterogeneous. With additional deficits in visuospatial attention, the two systems are hard to disentangle and it is not known whether impaired functional connectivity in the visual cortex is translative in nature or disrupted attentional modulation also contributes. In this study, we investigate functional connectivity modulation during a visuospatial attention task in patients with PD. In total, 15 PD and 16 age-matched healthy controls performed a visuospatial attention task while undergoing fMRI, in addition to a resting-state fMRI scan. Tensorial independent component analysis was used to investigate task-related network activity patterns. Independently, an atlas-based connectivity modulation analysis was performed using the task potency method. Spearman's rank correlation was calculated between task-related network expression, connectivity modulation, and clinical characteristics. Task-related networks including mostly visual, parietal, and prefrontal cortices were expressed to a significantly lesser degree in patients with PD (p < 0.027). Resting-state functional connectivity did not differ between the healthy and diseased cohorts. Connectivity between the precuneus and ventromedial prefrontal cortex was modulated to a higher degree in patients with PD (p < 0.004), while connections between the posterior parietal cortex and primary visual cortex, and also the superior frontal gyrus and opercular cortex were modulated to a lesser degree (p < 0.001 and p < 0.011). Task-related network expression and superior frontal gyrus–opercular cortex connectivity modulation were significantly associated with UPDRSIII motor scores and the Hoehn–Yahr stages (R = −0.72, p < 0.006 and R = −0.90, p < 0.001; R = −0.68, p < 0.01 and R = −0.71, p < 0.007). Task-related networks function differently in patients with PD in association with motor symptoms, whereas impaired modulation of visual and default-mode network connectivity was not correlated with motor function.
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spelling pubmed-93962582022-08-24 Modulation of cortical resting state functional connectivity during a visuospatial attention task in Parkinson's disease Veréb, Dániel Kovács, Márton Attila Antal, Szabolcs Kocsis, Krisztián Szabó, Nikoletta Kincses, Bálint Bozsik, Bence Faragó, Péter Tóth, Eszter Király, András Klivényi, Péter Zádori, Dénes Kincses, Zsigmond Tamás Front Neurol Neurology Visual dysfunction is a recognized early symptom of Parkinson's disease (PD) that partly scales motor symptoms, yet its background is heterogeneous. With additional deficits in visuospatial attention, the two systems are hard to disentangle and it is not known whether impaired functional connectivity in the visual cortex is translative in nature or disrupted attentional modulation also contributes. In this study, we investigate functional connectivity modulation during a visuospatial attention task in patients with PD. In total, 15 PD and 16 age-matched healthy controls performed a visuospatial attention task while undergoing fMRI, in addition to a resting-state fMRI scan. Tensorial independent component analysis was used to investigate task-related network activity patterns. Independently, an atlas-based connectivity modulation analysis was performed using the task potency method. Spearman's rank correlation was calculated between task-related network expression, connectivity modulation, and clinical characteristics. Task-related networks including mostly visual, parietal, and prefrontal cortices were expressed to a significantly lesser degree in patients with PD (p < 0.027). Resting-state functional connectivity did not differ between the healthy and diseased cohorts. Connectivity between the precuneus and ventromedial prefrontal cortex was modulated to a higher degree in patients with PD (p < 0.004), while connections between the posterior parietal cortex and primary visual cortex, and also the superior frontal gyrus and opercular cortex were modulated to a lesser degree (p < 0.001 and p < 0.011). Task-related network expression and superior frontal gyrus–opercular cortex connectivity modulation were significantly associated with UPDRSIII motor scores and the Hoehn–Yahr stages (R = −0.72, p < 0.006 and R = −0.90, p < 0.001; R = −0.68, p < 0.01 and R = −0.71, p < 0.007). Task-related networks function differently in patients with PD in association with motor symptoms, whereas impaired modulation of visual and default-mode network connectivity was not correlated with motor function. Frontiers Media S.A. 2022-08-09 /pmc/articles/PMC9396258/ /pubmed/36016543 http://dx.doi.org/10.3389/fneur.2022.927481 Text en Copyright © 2022 Veréb, Kovács, Antal, Kocsis, Szabó, Kincses, Bozsik, Faragó, Tóth, Király, Klivényi, Zádori and Kincses. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Veréb, Dániel
Kovács, Márton Attila
Antal, Szabolcs
Kocsis, Krisztián
Szabó, Nikoletta
Kincses, Bálint
Bozsik, Bence
Faragó, Péter
Tóth, Eszter
Király, András
Klivényi, Péter
Zádori, Dénes
Kincses, Zsigmond Tamás
Modulation of cortical resting state functional connectivity during a visuospatial attention task in Parkinson's disease
title Modulation of cortical resting state functional connectivity during a visuospatial attention task in Parkinson's disease
title_full Modulation of cortical resting state functional connectivity during a visuospatial attention task in Parkinson's disease
title_fullStr Modulation of cortical resting state functional connectivity during a visuospatial attention task in Parkinson's disease
title_full_unstemmed Modulation of cortical resting state functional connectivity during a visuospatial attention task in Parkinson's disease
title_short Modulation of cortical resting state functional connectivity during a visuospatial attention task in Parkinson's disease
title_sort modulation of cortical resting state functional connectivity during a visuospatial attention task in parkinson's disease
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396258/
https://www.ncbi.nlm.nih.gov/pubmed/36016543
http://dx.doi.org/10.3389/fneur.2022.927481
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