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Crystal structure of Ankyrin-G in complex with a fragment of Neurofascin reveals binding mechanisms required for integrity of the axon initial segment

The axon initial segment (AIS) has characteristically dense clustering of voltage-gated sodium channels (Nav), cell adhesion molecule Neurofascin 186 (Nfasc), and neuronal scaffold protein Ankyrin-G (AnkG) in neurons, which facilitates generation of an action potential and maintenance of axonal pola...

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Detalles Bibliográficos
Autores principales:	He, Liping, Jiang, Wenli, Li, Jianchao, Wang, Chao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396398/ https://www.ncbi.nlm.nih.gov/pubmed/35850303 http://dx.doi.org/10.1016/j.jbc.2022.102272

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