Activation of the canonical ER stress IRE1–XBP1 pathway by insulin regulates glucose and lipid metabolism

Knockout of the transcription factor X-box binding protein (XBP1) is known to decrease liver glucose production and lipogenesis. However, whether insulin can regulate gluconeogenesis and lipogenesis through XBP1 and how insulin activates the inositol-requiring enzyme-XBP1 ER stress pathway remains u...

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Detalles Bibliográficos
Autores principales: Peng, Jinghua, Qin, Caolitao, Ramatchandirin, Balamurugan, Pearah, Alexia, Guo, Shaodong, Hussain, Mehboob, Yu, Liqing, Wondisford, Fredric E., He, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396404/
https://www.ncbi.nlm.nih.gov/pubmed/35863429
http://dx.doi.org/10.1016/j.jbc.2022.102283

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