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The global change of gene expression pattern caused by PTEN mutation affects the prognosis of glioblastoma

Glioblastoma (GBM), an aggressive primary tumor, is common in humans, accounting for 12–15% of all intracranial tumors, and has median survival of fewer than 15 months. Since a growing body of evidence suggests that conventional drugs are ineffective against GBM, our goal is to find emerging therapi...

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Detalles Bibliográficos
Autores principales: Zhou, Shengjun, Wang, Haifeng, Huang, Yi, Wu, Yiwen, Lin, Zhiqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396408/
https://www.ncbi.nlm.nih.gov/pubmed/36016609
http://dx.doi.org/10.3389/fonc.2022.952521
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author Zhou, Shengjun
Wang, Haifeng
Huang, Yi
Wu, Yiwen
Lin, Zhiqing
author_facet Zhou, Shengjun
Wang, Haifeng
Huang, Yi
Wu, Yiwen
Lin, Zhiqing
author_sort Zhou, Shengjun
collection PubMed
description Glioblastoma (GBM), an aggressive primary tumor, is common in humans, accounting for 12–15% of all intracranial tumors, and has median survival of fewer than 15 months. Since a growing body of evidence suggests that conventional drugs are ineffective against GBM, our goal is to find emerging therapies that play a role in its treatment. This research constructs a risk model to predict the prognosis of GBM patients. A set of genes associated with GBM was taken from a GBM gene data bank, and clinical information on patients with GBM was retrieved from the Cancer Genome Atlas (TCGA) data bank. One-way Cox and Kaplan–Meier analyses were performed to identify genes in relation to prognosis. Groups were classified into high and low expression level of PTEN expression. Prognosis-related genes were further identified, and multi-factor Cox regression analysis was used to build risk score equations for the prognostic model to construct a survival prognostic model. The area under the ROC curve suggested that the pattern had high accuracy. When combined with nomogram analysis, GJB2 was considered an independent predictor of GBM prognosis. This study provides a potential prognostic predictive biological marker for GBM patients and confirms that GJB2 is a key gene for GBM progression.
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spelling pubmed-93964082022-08-24 The global change of gene expression pattern caused by PTEN mutation affects the prognosis of glioblastoma Zhou, Shengjun Wang, Haifeng Huang, Yi Wu, Yiwen Lin, Zhiqing Front Oncol Oncology Glioblastoma (GBM), an aggressive primary tumor, is common in humans, accounting for 12–15% of all intracranial tumors, and has median survival of fewer than 15 months. Since a growing body of evidence suggests that conventional drugs are ineffective against GBM, our goal is to find emerging therapies that play a role in its treatment. This research constructs a risk model to predict the prognosis of GBM patients. A set of genes associated with GBM was taken from a GBM gene data bank, and clinical information on patients with GBM was retrieved from the Cancer Genome Atlas (TCGA) data bank. One-way Cox and Kaplan–Meier analyses were performed to identify genes in relation to prognosis. Groups were classified into high and low expression level of PTEN expression. Prognosis-related genes were further identified, and multi-factor Cox regression analysis was used to build risk score equations for the prognostic model to construct a survival prognostic model. The area under the ROC curve suggested that the pattern had high accuracy. When combined with nomogram analysis, GJB2 was considered an independent predictor of GBM prognosis. This study provides a potential prognostic predictive biological marker for GBM patients and confirms that GJB2 is a key gene for GBM progression. Frontiers Media S.A. 2022-08-09 /pmc/articles/PMC9396408/ /pubmed/36016609 http://dx.doi.org/10.3389/fonc.2022.952521 Text en Copyright © 2022 Zhou, Wang, Huang, Wu and Lin https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Zhou, Shengjun
Wang, Haifeng
Huang, Yi
Wu, Yiwen
Lin, Zhiqing
The global change of gene expression pattern caused by PTEN mutation affects the prognosis of glioblastoma
title The global change of gene expression pattern caused by PTEN mutation affects the prognosis of glioblastoma
title_full The global change of gene expression pattern caused by PTEN mutation affects the prognosis of glioblastoma
title_fullStr The global change of gene expression pattern caused by PTEN mutation affects the prognosis of glioblastoma
title_full_unstemmed The global change of gene expression pattern caused by PTEN mutation affects the prognosis of glioblastoma
title_short The global change of gene expression pattern caused by PTEN mutation affects the prognosis of glioblastoma
title_sort global change of gene expression pattern caused by pten mutation affects the prognosis of glioblastoma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396408/
https://www.ncbi.nlm.nih.gov/pubmed/36016609
http://dx.doi.org/10.3389/fonc.2022.952521
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