Functional recovery and muscle atrophy in pre-clinical models of peripheral nerve transection and gap-grafting in mice: effects of 4-aminopyridine

We recently demonstrated a repurposing beneficial effect of 4-aminopyridine (4-AP), a potassium channel blocker, on functional recovery and muscle atrophy after sciatic nerve crush injury in rodents. However, this effect of 4-AP is unknown in nerve transection, gap, and grafting models. To evaluate...

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Detalles Bibliográficos
Autores principales: Lee, Jung Il, Talukder, M A Hassan, Karuman, Zara, Gurjar, Anagha A., Govindappa, Prem Kumar, Guddadarangaiah, Jagadeeshaprasad M., Manto, Kristen M., Wandling, Grant D., Hegarty, John P., Waning, David L., Elfar, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396510/
https://www.ncbi.nlm.nih.gov/pubmed/35900443
http://dx.doi.org/10.4103/1673-5374.346456

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