Amyloid Fibril Formation of Arctic Amyloid-β 1–42 Peptide is Efficiently Inhibited by the BRICHOS Domain

[Image: see text] Amyloid-β peptide (Aβ) aggregation is one of the hallmarks of Alzheimer’s disease (AD). Mutations in Aβ are associated with early onset familial AD, and the Arctic mutant E22G (Aβ(arc)) is an extremely aggregation-prone variant. Here, we show that BRICHOS, a natural anti-amyloid ch...

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Detalles Bibliográficos
Autores principales: Zhong, Xueying, Kumar, Rakesh, Wang, Yu, Biverstål, Henrik, Ingeborg Jegerschöld, Caroline, J B Koeck, Philip, Johansson, Jan, Abelein, Axel, Chen, Gefei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396614/
https://www.ncbi.nlm.nih.gov/pubmed/35876740
http://dx.doi.org/10.1021/acschembio.2c00344

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