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Refining the DC-targeting vaccination for preventing emerging infectious diseases
The development of safe, long-term, effective vaccines is still a challenge for many infectious diseases. Thus, the search of new vaccine strategies and production platforms that allow rapidly and effectively responding against emerging or reemerging pathogens has become a priority in the last years...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396646/ https://www.ncbi.nlm.nih.gov/pubmed/36016929 http://dx.doi.org/10.3389/fimmu.2022.949779 |
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author | Pastor, Yadira Ghazzaui, Nour Hammoudi, Adele Centlivre, Mireille Cardinaud, Sylvain Levy, Yves |
author_facet | Pastor, Yadira Ghazzaui, Nour Hammoudi, Adele Centlivre, Mireille Cardinaud, Sylvain Levy, Yves |
author_sort | Pastor, Yadira |
collection | PubMed |
description | The development of safe, long-term, effective vaccines is still a challenge for many infectious diseases. Thus, the search of new vaccine strategies and production platforms that allow rapidly and effectively responding against emerging or reemerging pathogens has become a priority in the last years. Targeting the antigens directly to dendritic cells (DCs) has emerged as a new approach to enhance the immune response after vaccination. This strategy is based on the fusion of the antigens of choice to monoclonal antibodies directed against specific DC surface receptors such as CD40. Since time is essential, in silico approaches are of high interest to select the most immunogenic and conserved epitopes to improve the T- and B-cells responses. The purpose of this review is to present the advances in DC vaccination, with special focus on DC targeting vaccines and epitope mapping strategies and provide a new framework for improving vaccine responses against infectious diseases. |
format | Online Article Text |
id | pubmed-9396646 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93966462022-08-24 Refining the DC-targeting vaccination for preventing emerging infectious diseases Pastor, Yadira Ghazzaui, Nour Hammoudi, Adele Centlivre, Mireille Cardinaud, Sylvain Levy, Yves Front Immunol Immunology The development of safe, long-term, effective vaccines is still a challenge for many infectious diseases. Thus, the search of new vaccine strategies and production platforms that allow rapidly and effectively responding against emerging or reemerging pathogens has become a priority in the last years. Targeting the antigens directly to dendritic cells (DCs) has emerged as a new approach to enhance the immune response after vaccination. This strategy is based on the fusion of the antigens of choice to monoclonal antibodies directed against specific DC surface receptors such as CD40. Since time is essential, in silico approaches are of high interest to select the most immunogenic and conserved epitopes to improve the T- and B-cells responses. The purpose of this review is to present the advances in DC vaccination, with special focus on DC targeting vaccines and epitope mapping strategies and provide a new framework for improving vaccine responses against infectious diseases. Frontiers Media S.A. 2022-08-09 /pmc/articles/PMC9396646/ /pubmed/36016929 http://dx.doi.org/10.3389/fimmu.2022.949779 Text en Copyright © 2022 Pastor, Ghazzaui, Hammoudi, Centlivre, Cardinaud and Levy https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Pastor, Yadira Ghazzaui, Nour Hammoudi, Adele Centlivre, Mireille Cardinaud, Sylvain Levy, Yves Refining the DC-targeting vaccination for preventing emerging infectious diseases |
title | Refining the DC-targeting vaccination for preventing emerging infectious diseases |
title_full | Refining the DC-targeting vaccination for preventing emerging infectious diseases |
title_fullStr | Refining the DC-targeting vaccination for preventing emerging infectious diseases |
title_full_unstemmed | Refining the DC-targeting vaccination for preventing emerging infectious diseases |
title_short | Refining the DC-targeting vaccination for preventing emerging infectious diseases |
title_sort | refining the dc-targeting vaccination for preventing emerging infectious diseases |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396646/ https://www.ncbi.nlm.nih.gov/pubmed/36016929 http://dx.doi.org/10.3389/fimmu.2022.949779 |
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