Synthesis of MDM2-p53 Inhibitor BI-0282 via a Dipolar Cycloaddition and Late-Stage Davis–Beirut Reaction

[Image: see text] Herein, we report the structure and synthesis of the potent MDM2-p53 inhibitor BI-0282. The complex spirooxindole scaffold bearing four stereocenters embedded in a rigid polycyclic ring-system was effectively prepared on a multi-gram scale in only five synthesis steps employing a t...

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Detalles Bibliográficos
Autores principales: Ramharter, Juergen, Kulhanek, Michael, Dettling, Maike, Gmaschitz, Gerhard, Karolyi-Oezguer, Jale, Weinstabl, Harald, Gollner, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396656/
https://www.ncbi.nlm.nih.gov/pubmed/36032359
http://dx.doi.org/10.1021/acs.oprd.2c00192

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396656/
https://www.ncbi.nlm.nih.gov/pubmed/36032359
http://dx.doi.org/10.1021/acs.oprd.2c00192

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