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Directed Evolution of (R)-2-Hydroxyglutarate Dehydrogenase Improves 2-Oxoadipate Reduction by 2 Orders of Magnitude

[Image: see text] Pathway engineering is commonly employed to improve the production of various metabolites but may incur in bottlenecks due to the low catalytic activity of a particular reaction step. The reduction of 2-oxoadipate to (R)-2-hydroxyadipate is a key reaction in metabolic pathways that...

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Detalles Bibliográficos
Autores principales:	Saez-Jimenez, Veronica, Scrima, Simone, Lambrughi, Matteo, Papaleo, Elena, Mapelli, Valeria, Engqvist, Martin K. M., Olsson, Lisbeth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396657/ https://www.ncbi.nlm.nih.gov/pubmed/35939387 http://dx.doi.org/10.1021/acssynbio.2c00162

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