Discovery of 8-Hydroxyquinoline as a Histamine Receptor 2 Blocker Scaffold

[Image: see text] Histamine receptor 2 (HR(H2)) activation in the stomach results in gastric acid secretion, and HR(H2) blockers are used for the treatment of peptidic ulcers and acid reflux. Over-the-counter HR(H2) blockers carry a five-membered aromatic heterocycle, with two of them additionally c...

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Detalles Bibliográficos
Autores principales: Marquez-Gomez, Paola L., Kruyer, Nicholas S., Eisen, Sara L., Torp, Lily R., Howie, Rebecca L., Jones, Elizabeth V., France, Stefan, Peralta-Yahya, Pamela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396701/
https://www.ncbi.nlm.nih.gov/pubmed/35930594
http://dx.doi.org/10.1021/acssynbio.2c00205

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