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Advances in the use of exosomes for the treatment of ALI/ARDS

Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a critical clinical syndrome with high morbidity and mortality. Currently, the primary treatment for ALI/ARDS is mainly symptomatic therapy such as mechanical ventilation and fluid management. Due to the lack of effective treatmen...

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Detalles Bibliográficos
Autores principales: Liu, Chang, Xiao, Kun, Xie, Lixin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396740/
https://www.ncbi.nlm.nih.gov/pubmed/36016948
http://dx.doi.org/10.3389/fimmu.2022.971189
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author Liu, Chang
Xiao, Kun
Xie, Lixin
author_facet Liu, Chang
Xiao, Kun
Xie, Lixin
author_sort Liu, Chang
collection PubMed
description Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a critical clinical syndrome with high morbidity and mortality. Currently, the primary treatment for ALI/ARDS is mainly symptomatic therapy such as mechanical ventilation and fluid management. Due to the lack of effective treatment strategies, most ALI/ARDS patients face a poor prognosis. The discovery of exosomes has created a promising prospect for the treatment of ALI/ARDS. Exosomes can exert anti-inflammatory effects, inhibit apoptosis, and promote cell regeneration. The microRNA contained in exosomes can participate in intercellular communication and play an immunomodulatory role in ALI/ARDS disease models. This review discusses the possible mechanisms of exosomes in ALI/ARDS to facilitate the development of innovative treatments for ALI/ARDS.
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spelling pubmed-93967402022-08-24 Advances in the use of exosomes for the treatment of ALI/ARDS Liu, Chang Xiao, Kun Xie, Lixin Front Immunol Immunology Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a critical clinical syndrome with high morbidity and mortality. Currently, the primary treatment for ALI/ARDS is mainly symptomatic therapy such as mechanical ventilation and fluid management. Due to the lack of effective treatment strategies, most ALI/ARDS patients face a poor prognosis. The discovery of exosomes has created a promising prospect for the treatment of ALI/ARDS. Exosomes can exert anti-inflammatory effects, inhibit apoptosis, and promote cell regeneration. The microRNA contained in exosomes can participate in intercellular communication and play an immunomodulatory role in ALI/ARDS disease models. This review discusses the possible mechanisms of exosomes in ALI/ARDS to facilitate the development of innovative treatments for ALI/ARDS. Frontiers Media S.A. 2022-08-09 /pmc/articles/PMC9396740/ /pubmed/36016948 http://dx.doi.org/10.3389/fimmu.2022.971189 Text en Copyright © 2022 Liu, Xiao and Xie https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Liu, Chang
Xiao, Kun
Xie, Lixin
Advances in the use of exosomes for the treatment of ALI/ARDS
title Advances in the use of exosomes for the treatment of ALI/ARDS
title_full Advances in the use of exosomes for the treatment of ALI/ARDS
title_fullStr Advances in the use of exosomes for the treatment of ALI/ARDS
title_full_unstemmed Advances in the use of exosomes for the treatment of ALI/ARDS
title_short Advances in the use of exosomes for the treatment of ALI/ARDS
title_sort advances in the use of exosomes for the treatment of ali/ards
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396740/
https://www.ncbi.nlm.nih.gov/pubmed/36016948
http://dx.doi.org/10.3389/fimmu.2022.971189
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