DNA methylation analysis of normal colon organoids from familial adenomatous polyposis patients reveals novel insight into colon cancer development

BACKGROUND: Familial adenomatous polyposis (FAP) is an inherited colorectal cancer (CRC) syndrome resulting from germ line mutations in the adenomatous polyposis coli (APC) gene. While FAP accounts for less than 1% of all CRC cases, loss of APC expression is seen in > 80% of non-hereditary CRCs....

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Detalles Bibliográficos
Autores principales: Devall, Matthew A., Eaton, Stephen, Ali, Mourad Wagdy, Dampier, Christopher H., Weisenberger, Daniel, Powell, Steven M., Li, Li, Casey, Graham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396789/
https://www.ncbi.nlm.nih.gov/pubmed/35999641
http://dx.doi.org/10.1186/s13148-022-01324-5

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