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Effects of cognitive ageing trajectories on multiple adverse outcomes among Chinese community-dwelling elderly population

BACKGROUND: Whether cognitive ageing trajectory is related to common functional deficits independent of initial cognitive function remains inconclusive. We aimed to explore the adverse health effect and potential predictive factors of distinct cognitive trajectories among Chinese older adults. METHO...

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Autores principales: Han, Chao, An, Jing, Chan, Piu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396872/
https://www.ncbi.nlm.nih.gov/pubmed/35996087
http://dx.doi.org/10.1186/s12877-022-03387-8
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author Han, Chao
An, Jing
Chan, Piu
author_facet Han, Chao
An, Jing
Chan, Piu
author_sort Han, Chao
collection PubMed
description BACKGROUND: Whether cognitive ageing trajectory is related to common functional deficits independent of initial cognitive function remains inconclusive. We aimed to explore the adverse health effect and potential predictive factors of distinct cognitive trajectories among Chinese older adults. METHODS: Three thousand five hundred eighty-one community-dwelling older adults who completed three consecutive cognitive function examinations with the Mini-Mental State Examination (MMSE) over 5 years and were without cognitive impairment at enrollment were included. A group-based trajectory model was used to estimate cognitive ageing trajectories. Multivariable-adjusted odds ratio (OR) and 95% confidence intervals (CI) were computed with logistic regression models to identify potential baseline determinants and health effect of cognitive trajectories on various adverse outcomes. RESULTS: Two distinct cognitive ageing trajectories were identified with about 5.3% of the study participants ascribed to the rapidly decreasing group. Subjects with rapidly decreasing cognition showed significantly higher odds (OR, 95%CI) of experiencing frailty (4.04, 2.77–5.86), falls (2.01, 1.05–3.70), balance impairment (4.20, 2.75–6.38), high fall risk (5.66, 2.67–11.77) based on the Tinetti total score, disability in activities of daily living (1.76, 1.19–2.56), disability in instrumental activities of daily living (1.52, 1.05–2.19), and motor cognitive risk syndrome (2.24, 1.23–3.98) compared with their steadily decreasing counterparts. Individuals with older age, low education level, no marriage, high score of rapid eye movement behavior disorders, poor physical and cognitive function at baseline were more predisposed to an accelerated cognitive decline. CONCLUSIONS: Faster cognitive decline was independently associated with higher risk of multiple adverse events. Our findings put more emphasis on a routine and constant surveillance of cognitive function among community-dwelling older adults. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12877-022-03387-8.
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spelling pubmed-93968722022-08-24 Effects of cognitive ageing trajectories on multiple adverse outcomes among Chinese community-dwelling elderly population Han, Chao An, Jing Chan, Piu BMC Geriatr Research BACKGROUND: Whether cognitive ageing trajectory is related to common functional deficits independent of initial cognitive function remains inconclusive. We aimed to explore the adverse health effect and potential predictive factors of distinct cognitive trajectories among Chinese older adults. METHODS: Three thousand five hundred eighty-one community-dwelling older adults who completed three consecutive cognitive function examinations with the Mini-Mental State Examination (MMSE) over 5 years and were without cognitive impairment at enrollment were included. A group-based trajectory model was used to estimate cognitive ageing trajectories. Multivariable-adjusted odds ratio (OR) and 95% confidence intervals (CI) were computed with logistic regression models to identify potential baseline determinants and health effect of cognitive trajectories on various adverse outcomes. RESULTS: Two distinct cognitive ageing trajectories were identified with about 5.3% of the study participants ascribed to the rapidly decreasing group. Subjects with rapidly decreasing cognition showed significantly higher odds (OR, 95%CI) of experiencing frailty (4.04, 2.77–5.86), falls (2.01, 1.05–3.70), balance impairment (4.20, 2.75–6.38), high fall risk (5.66, 2.67–11.77) based on the Tinetti total score, disability in activities of daily living (1.76, 1.19–2.56), disability in instrumental activities of daily living (1.52, 1.05–2.19), and motor cognitive risk syndrome (2.24, 1.23–3.98) compared with their steadily decreasing counterparts. Individuals with older age, low education level, no marriage, high score of rapid eye movement behavior disorders, poor physical and cognitive function at baseline were more predisposed to an accelerated cognitive decline. CONCLUSIONS: Faster cognitive decline was independently associated with higher risk of multiple adverse events. Our findings put more emphasis on a routine and constant surveillance of cognitive function among community-dwelling older adults. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12877-022-03387-8. BioMed Central 2022-08-22 /pmc/articles/PMC9396872/ /pubmed/35996087 http://dx.doi.org/10.1186/s12877-022-03387-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Han, Chao
An, Jing
Chan, Piu
Effects of cognitive ageing trajectories on multiple adverse outcomes among Chinese community-dwelling elderly population
title Effects of cognitive ageing trajectories on multiple adverse outcomes among Chinese community-dwelling elderly population
title_full Effects of cognitive ageing trajectories on multiple adverse outcomes among Chinese community-dwelling elderly population
title_fullStr Effects of cognitive ageing trajectories on multiple adverse outcomes among Chinese community-dwelling elderly population
title_full_unstemmed Effects of cognitive ageing trajectories on multiple adverse outcomes among Chinese community-dwelling elderly population
title_short Effects of cognitive ageing trajectories on multiple adverse outcomes among Chinese community-dwelling elderly population
title_sort effects of cognitive ageing trajectories on multiple adverse outcomes among chinese community-dwelling elderly population
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396872/
https://www.ncbi.nlm.nih.gov/pubmed/35996087
http://dx.doi.org/10.1186/s12877-022-03387-8
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