GRK3 is a poor prognosticator and serves as a therapeutic target in advanced gastric adenocarcinoma

BACKGROUND: G protein-coupled receptor (GPCR) is the most targeted protein family by the FDA-approved drugs. GPCR-kinase 3 (GRK3) is critical for GPCR signaling. Our genomic analysis showed that GRK3 expression correlated with poor prognosis of gastric adenocarcinoma (GAC) patients. However, GRK3’s...

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Detalles Bibliográficos
Autores principales: Li, Yuan, Fan, Yibo, Xu, Jinbang, Huo, Longfei, Scott, Ailing W., Jin, Jiankang, Yang, Boxuan, Shao, Shan, Ma, Lang, Wang, Ying, Yao, Xiaodan, Pool Pizzi, Melissa, Sewastjanow Da Silva, Matheus, Zhang, Guoliang, Zhuo, Lijuan, Cho, Eun Jeong, Dalby, Kevin N., Shanbhag, Namita D., Wang, Zhenning, Li, Wenliang, Song, Shumei, Ajani, Jaffer A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396876/
https://www.ncbi.nlm.nih.gov/pubmed/35996148
http://dx.doi.org/10.1186/s13046-022-02463-6

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