Ubiquitination at the lysine 27 residue of the Parkin ubiquitin-like domain is suggestive of a new mechanism of Parkin activation

The mitochondrial kinase PTEN-induced kinase 1 (PINK1) and cytosolic ubiquitin ligase (E3) Parkin/PRKN are involved in mitochondrial quality control responses. PINK1 phosphorylates ubiquitin and the Parkin ubiquitin-like (Ubl) domain at serine 65 and promotes Parkin activation and translocation to d...

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Detalles Bibliográficos
Autores principales: Liu, Jun-Yi, Inoshita, Tsuyoshi, Shiba-Fukushima, Kahori, Yoshida, Shigeharu, Ogata, Kosuke, Ishihama, Yasushi, Imai, Yuzuru, Hattori, Nobutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396936/
https://www.ncbi.nlm.nih.gov/pubmed/35313349
http://dx.doi.org/10.1093/hmg/ddac064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396936/
https://www.ncbi.nlm.nih.gov/pubmed/35313349
http://dx.doi.org/10.1093/hmg/ddac064

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