Cargando…

Multiple spatial scale mapping of time-resolved brain network reconfiguration during evoked pain in patients with rheumatoid arthritis

Functional brain networks and the perception of pain can fluctuate over time. However, how the time-dependent reconfiguration of functional brain networks contributes to chronic pain remains largely unexplained. Here, we explored time-varying changes in brain network integration and segregation duri...

Descripción completa

Detalles Bibliográficos
Autores principales: Fanton, Silvia, Altawil, Reem, Ellerbrock, Isabel, Lampa, Jon, Kosek, Eva, Fransson, Peter, Thompson, William H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9397124/
https://www.ncbi.nlm.nih.gov/pubmed/36017179
http://dx.doi.org/10.3389/fnins.2022.942136
_version_ 1784772066169323520
author Fanton, Silvia
Altawil, Reem
Ellerbrock, Isabel
Lampa, Jon
Kosek, Eva
Fransson, Peter
Thompson, William H.
author_facet Fanton, Silvia
Altawil, Reem
Ellerbrock, Isabel
Lampa, Jon
Kosek, Eva
Fransson, Peter
Thompson, William H.
author_sort Fanton, Silvia
collection PubMed
description Functional brain networks and the perception of pain can fluctuate over time. However, how the time-dependent reconfiguration of functional brain networks contributes to chronic pain remains largely unexplained. Here, we explored time-varying changes in brain network integration and segregation during pain over a disease-affected area (joint) compared to a neutral site (thumbnail) in 28 patients with rheumatoid arthritis (RA) in comparison with 22 healthy controls (HC). During functional magnetic resonance imaging, all subjects received individually calibrated pain pressures corresponding to visual analog scale 50 mm at joint and thumbnail. We implemented a novel approach to track changes of task-based network connectivity over time. Within this framework, we quantified measures of integration (participation coefficient, PC) and segregation (within-module degree z-score). Using these network measures at multiple spatial scales, both at the level of single nodes (brain regions) and communities (clusters of nodes), we found that PC at the community level was generally higher in RA patients compared to HC during and after painful pressure over the inflamed joint and corresponding site in HC. This shows that all brain communities integrate more in RA patients than in HC for time points following painful stimulation to a disease-relevant body site. However, the elevated community-related integration seen in patients appeared to not pertain uniquely to painful stimulation at the inflamed joint, but also at the neutral thumbnail, as integration and segregation at the community level did not differ across body sites in patients. Moreover, there was no specific nodal contribution to brain network integration or segregation. Altogether, our findings indicate widespread and persistent changes in network interaction in RA patients compared to HC in response to painful stimulation.
format Online
Article
Text
id pubmed-9397124
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-93971242022-08-24 Multiple spatial scale mapping of time-resolved brain network reconfiguration during evoked pain in patients with rheumatoid arthritis Fanton, Silvia Altawil, Reem Ellerbrock, Isabel Lampa, Jon Kosek, Eva Fransson, Peter Thompson, William H. Front Neurosci Neuroscience Functional brain networks and the perception of pain can fluctuate over time. However, how the time-dependent reconfiguration of functional brain networks contributes to chronic pain remains largely unexplained. Here, we explored time-varying changes in brain network integration and segregation during pain over a disease-affected area (joint) compared to a neutral site (thumbnail) in 28 patients with rheumatoid arthritis (RA) in comparison with 22 healthy controls (HC). During functional magnetic resonance imaging, all subjects received individually calibrated pain pressures corresponding to visual analog scale 50 mm at joint and thumbnail. We implemented a novel approach to track changes of task-based network connectivity over time. Within this framework, we quantified measures of integration (participation coefficient, PC) and segregation (within-module degree z-score). Using these network measures at multiple spatial scales, both at the level of single nodes (brain regions) and communities (clusters of nodes), we found that PC at the community level was generally higher in RA patients compared to HC during and after painful pressure over the inflamed joint and corresponding site in HC. This shows that all brain communities integrate more in RA patients than in HC for time points following painful stimulation to a disease-relevant body site. However, the elevated community-related integration seen in patients appeared to not pertain uniquely to painful stimulation at the inflamed joint, but also at the neutral thumbnail, as integration and segregation at the community level did not differ across body sites in patients. Moreover, there was no specific nodal contribution to brain network integration or segregation. Altogether, our findings indicate widespread and persistent changes in network interaction in RA patients compared to HC in response to painful stimulation. Frontiers Media S.A. 2022-08-09 /pmc/articles/PMC9397124/ /pubmed/36017179 http://dx.doi.org/10.3389/fnins.2022.942136 Text en Copyright © 2022 Fanton, Altawil, Ellerbrock, Lampa, Kosek, Fransson and Thompson. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Fanton, Silvia
Altawil, Reem
Ellerbrock, Isabel
Lampa, Jon
Kosek, Eva
Fransson, Peter
Thompson, William H.
Multiple spatial scale mapping of time-resolved brain network reconfiguration during evoked pain in patients with rheumatoid arthritis
title Multiple spatial scale mapping of time-resolved brain network reconfiguration during evoked pain in patients with rheumatoid arthritis
title_full Multiple spatial scale mapping of time-resolved brain network reconfiguration during evoked pain in patients with rheumatoid arthritis
title_fullStr Multiple spatial scale mapping of time-resolved brain network reconfiguration during evoked pain in patients with rheumatoid arthritis
title_full_unstemmed Multiple spatial scale mapping of time-resolved brain network reconfiguration during evoked pain in patients with rheumatoid arthritis
title_short Multiple spatial scale mapping of time-resolved brain network reconfiguration during evoked pain in patients with rheumatoid arthritis
title_sort multiple spatial scale mapping of time-resolved brain network reconfiguration during evoked pain in patients with rheumatoid arthritis
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9397124/
https://www.ncbi.nlm.nih.gov/pubmed/36017179
http://dx.doi.org/10.3389/fnins.2022.942136
work_keys_str_mv AT fantonsilvia multiplespatialscalemappingoftimeresolvedbrainnetworkreconfigurationduringevokedpaininpatientswithrheumatoidarthritis
AT altawilreem multiplespatialscalemappingoftimeresolvedbrainnetworkreconfigurationduringevokedpaininpatientswithrheumatoidarthritis
AT ellerbrockisabel multiplespatialscalemappingoftimeresolvedbrainnetworkreconfigurationduringevokedpaininpatientswithrheumatoidarthritis
AT lampajon multiplespatialscalemappingoftimeresolvedbrainnetworkreconfigurationduringevokedpaininpatientswithrheumatoidarthritis
AT kosekeva multiplespatialscalemappingoftimeresolvedbrainnetworkreconfigurationduringevokedpaininpatientswithrheumatoidarthritis
AT franssonpeter multiplespatialscalemappingoftimeresolvedbrainnetworkreconfigurationduringevokedpaininpatientswithrheumatoidarthritis
AT thompsonwilliamh multiplespatialscalemappingoftimeresolvedbrainnetworkreconfigurationduringevokedpaininpatientswithrheumatoidarthritis