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Decoupling Growth and Production by Removing the Origin of Replication from a Bacterial Chromosome

[Image: see text] Efficient production of biochemicals and proteins in cell factories frequently benefits from a two-stage bioprocess in which growth and production phases are decoupled. Here, we describe a novel growth switch based on the permanent removal of the origin of replication (oriC) from t...

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Detalles Bibliográficos
Autores principales: Kasari, Marje, Kasari, Villu, Kärmas, Mirjam, Jõers, Arvi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9397407/
https://www.ncbi.nlm.nih.gov/pubmed/35798328
http://dx.doi.org/10.1021/acssynbio.1c00618

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