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Combined fibre atrophy and decreased muscle regeneration capacity driven by mitochondrial DNA alterations underlie the development of sarcopenia

BACKGROUND: Mitochondrial dysfunction caused by mitochondrial (mtDNA) deletions have been associated with skeletal muscle atrophy and myofibre loss. However, whether such defects occurring in myofibres cause sarcopenia is unclear. Also, the contribution of mtDNA alterations in muscle stem cells (MuS...

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Detalles Bibliográficos
Autores principales:	Kimoloi, Sammy, Sen, Ayesha, Guenther, Stefan, Braun, Thomas, Brügmann, Tobias, Sasse, Philipp, Wiesner, Rudolf J., Pla‐Martín, David, Baris, Olivier R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9397496/ https://www.ncbi.nlm.nih.gov/pubmed/35765148 http://dx.doi.org/10.1002/jcsm.13026

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