A disease‐associated missense mutation in CYP4F3 affects the metabolism of leukotriene B4 via disruption of electron transfer

BACKGROUND: Cytochrome P450 4F3 (CYP4F3) is an ω‐hydroxylase that oxidizes leukotriene B4 (LTB4), prostaglandins, and fatty acid epoxides. LTB4 is synthesized by leukocytes and acts as a chemoattractant for neutrophils, making it an essential component of the innate immune system. Recently, involvem...

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Detalles Bibliográficos
Autores principales: Smeets, Elien, Huang, Shengyun, Lee, Xiao Yin, Van Nieuwenhove, Erika, Helsen, Christine, Handle, Florian, Moris, Lisa, El Kharraz, Sarah, Eerlings, Roy, Devlies, Wout, Willemsen, Mathijs, Bücken, Leoni, Prezzemolo, Teresa, Humblet‐Baron, Stephanie, Voet, Arnout, Rochtus, Anne, Van Schepdael, Ann, de Zegher, Francis, Claessens, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9397552/
https://www.ncbi.nlm.nih.gov/pubmed/35686338
http://dx.doi.org/10.1002/jcsm.13022

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