Cargando…

Computational Analysis of Cholangiocarcinoma Phosphoproteomes Identifies Patient-Specific Drug Targets

Cholangiocarcinoma is a form of hepatobiliary cancer with an abysmal prognosis. Despite advances in our understanding of cholangiocarcinoma pathophysiology and its genomic landscape, targeted therapies have not yet made a significant impact on its clinical management. The low response rates of targe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Khorsandi, Shirin Elizabeth, Dokal, Arran D., Rajeeve, Vinothini, Britton, David J., Illingworth, Megan S., Heaton, Nigel, Cutillas, Pedro R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2021
Materias:	Convergence and Technologies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9397618/ https://www.ncbi.nlm.nih.gov/pubmed/34551960 http://dx.doi.org/10.1158/0008-5472.CAN-21-0955

Ejemplares similares

Quantitative Analysis of Tyrosine Phosphorylation from FFPE Tissues Reveals Patient-Specific Signaling Networks
por: Kohale, Ishwar N., et al.
Publicado: (2021)

Spectral Endoscopy Enhances Contrast for Neoplasia in Surveillance of Barrett's Esophagus
por: Waterhouse, Dale J., et al.
Publicado: (2021)

Prostate Cancer Risk Stratification via Nondestructive 3D Pathology with Deep Learning–Assisted Gland Analysis
por: Xie, Weisi, et al.
Publicado: (2022)

Quantification of T- and B-cell Immune Receptor Distribution Diversity Characterizes Immune Cell Infiltration and Lymphocyte Heterogeneity in Clear Cell Renal Cell Carcinoma
por: Ferrall-Fairbanks, Meghan C., et al.
Publicado: (2022)

A Microfluidic Cancer-on-Chip Platform Predicts Drug Response Using Organotypic Tumor Slice Culture
por: Chakrabarty, Sanjiban, et al.
Publicado: (2022)

Predicting Molecular Phenotypes from Histopathology Images: A Transcriptome-Wide Expression–Morphology Analysis in Breast Cancer
por: Wang, Yinxi, et al.
Publicado: (2021)

Imaging Glioblastoma Response to Radiotherapy Using (2)H Magnetic Resonance Spectroscopy Measurements of Fumarate Metabolism
por: Hesse, Friederike, et al.
Publicado: (2022)

Delineating the RAS Conformational Landscape
por: Parker, Mitchell I., et al.
Publicado: (2022)

Photoacoustic Tomography Detects Response and Resistance to Bevacizumab in Breast Cancer Mouse Models
por: Quiros-Gonzalez, Isabel, et al.
Publicado: (2022)

Chemotherapy-Induced Collagen IV Drives Cancer Cell Motility through Activation of Src and Focal Adhesion Kinase
por: Fatherree, Jackson P., et al.
Publicado: (2022)

Quantitative Micro-Elastography Enables In Vivo Detection of Residual Cancer in the Surgical Cavity during Breast-Conserving Surgery
por: Gong, Peijun, et al.
Publicado: (2022)

A Cell-Fate Reprogramming Strategy Reverses Epithelial-to-Mesenchymal Transition of Lung Cancer Cells While Avoiding Hybrid States
por: Kim, Namhee, et al.
Publicado: (2023)

Stimulated Raman Scattering Microscopy Enables Gleason Scoring of Prostate Core Needle Biopsy by a Convolutional Neural Network
por: Ao, Jianpeng, et al.
Publicado: (2023)

Mathematical Modeling and Mutational Analysis Reveal Optimal Therapy to Prevent Malignant Transformation in Grade II IDH-Mutant Gliomas
por: Aoki, Kosuke, et al.
Publicado: (2021)

Bayesian Machine Learning Enables Identification of Transcriptional Network Disruptions Associated with Drug-Resistant Prostate Cancer
por: Blatti, Charles, et al.
Publicado: (2023)

Drug ranking using machine learning systematically predicts the efficacy of anti-cancer drugs
por: Gerdes, Henry, et al.
Publicado: (2021)

LGG-57. SIGNALLING MECHANISMS IN PAEDIATRIC LOW-GRADE GLIOMA
por: Patel, Ankit, et al.
Publicado: (2020)

Polyunsaturated Fatty Acid–Bound α-Fetoprotein Promotes Immune Suppression by Altering Human Dendritic Cell Metabolism
por: Munson, Paul V., et al.
Publicado: (2023)

The Ratio of Key Metabolic Transcripts Is a Predictive Biomarker of Breast Cancer Metastasis to the Lung
por: Mathur, Deepti, et al.
Publicado: (2023)

Profiling the Somatic Mutational Landscape of Breast Tumors from Hispanic/Latina Women Reveals Conserved and Unique Characteristics
por: Ding, Yuan Chun, et al.
Publicado: (2023)

BRCA1 Insufficiency Induces a Hypersialylated Acidic Tumor Microenvironment That Promotes Metastasis and Immunotherapy Resistance
por: Shu, Xiaodong, et al.
Publicado: (2023)

LGG-44. Multi-omic analysis reveals integrated signalling networks in paediatric low-grade glioma
por: Woodward, Lewis, et al.
Publicado: (2022)

Sequence and Structure-Based Analysis of Specificity Determinants in Eukaryotic Protein Kinases
por: Bradley, David, et al.
Publicado: (2021)

Perioperative plasma mitochondrial DNA dynamics and correlation with inflammation during infantile cardiopulmonary bypass
por: Xu, Fei, et al.
Publicado: (2017)

Morphometry of the triangle of Koch and position of the coronary sinus opening in cadaveric fetal hearts
por: Shanubhogue, Sharan, et al.
Publicado: (2017)

Methylenetetrahydrofolate reductase C677T and methionine synthase A2756G gene polymorphisms and associated risk of cardiovascular diseases: A study from Jammu region
por: Raina, Jyotdeep K., et al.
Publicado: (2016)

Contemporary Strategies in the Management of Hepatocellular Carcinoma
por: Khorsandi, Shirin Elizabeth, et al.
Publicado: (2012)

Withanolide Metabolites Inhibit PI3K/AKT and MAPK Pro-Survival Pathways and Induce Apoptosis in Acute Myeloid Leukemia Cells
por: Akhtar, Nosheen, et al.
Publicado: (2020)

The cytotoxic action of BCI is not dependent on its stated DUSP1 or DUSP6 targets in neuroblastoma cells
por: Thompson, Elliott M., et al.
Publicado: (2022)

eEF2K Activity Determines Synergy to Cotreatment of Cancer Cells With PI3K and MEK Inhibitors
por: Hijazi, Maruan, et al.
Publicado: (2022)

Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes
por: Casado, Pedro, et al.
Publicado: (2023)

Principles of phosphoproteomics and applications in cancer research
por: Higgins, Luke, et al.
Publicado: (2023)

S124: PHOSPHOPROTEOMICS ACCURATELY PREDICTS RESPONSES TO MIDOSTAURIN PLUS CHEMOTHERAPY IN TWO INDEPENDENT COHORTS OF FLT3 MUTANT-POSITIVE ACUTE MYELOID LEUKAEMIA
por: Dokal, Arran, et al.
Publicado: (2023)

Phosphoproteomics-Based Profiling of Kinase Activities in Cancer Cells
por: Wirbel, Jakob, et al.
Publicado: (2017)

Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma
por: Freire-Benéitez, Verónica, et al.
Publicado: (2021)

Correction to ‘Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma’
por: Freire-Benéitez, Verónica, et al.
Publicado: (2021)

Genome instability is a consequence of transcription deficiency in patients with bone marrow failure harboring biallelic ERCC6L2 variants
por: Tummala, Hemanth, et al.
Publicado: (2018)

Shedding of bevacizumab in tumour cells-derived extracellular vesicles as a new therapeutic escape mechanism in glioblastoma
por: Simon, Thomas, et al.
Publicado: (2018)

Feasibility of Phosphoproteomics on Leftover Samples After RNA Extraction With Guanidinium Thiocyanate
por: Rolfs, Frank, et al.
Publicado: (2021)

Hepatic arterial infusion chemotherapy versus transarterial chemoembolization for unresectable hepatocellular carcinoma: A systematic review with meta-analysis
por: Si, Tengfei, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_7id4rf75j659lljhtna1og1bo8