Cargando…

Predicting Molecular Phenotypes from Histopathology Images: A Transcriptome-Wide Expression–Morphology Analysis in Breast Cancer

Molecular profiling is central in cancer precision medicine but remains costly and is based on tumor average profiles. Morphologic patterns observable in histopathology sections from tumors are determined by the underlying molecular phenotype and therefore have the potential to be exploited for pred...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Yinxi, Kartasalo, Kimmo, Weitz, Philippe, Ács, Balázs, Valkonen, Masi, Larsson, Christer, Ruusuvuori, Pekka, Hartman, Johan, Rantalainen, Mattias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2021
Materias:	Convergence and Technologies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9397635/ https://www.ncbi.nlm.nih.gov/pubmed/34341074 http://dx.doi.org/10.1158/0008-5472.CAN-21-0482

Ejemplares similares

Transcriptome-wide prediction of prostate cancer gene expression from histopathology images using co-expression-based convolutional neural networks
por: Weitz, Philippe, et al.
Publicado: (2022)

Spectral Endoscopy Enhances Contrast for Neoplasia in Surveillance of Barrett's Esophagus
por: Waterhouse, Dale J., et al.
Publicado: (2021)

Prostate Cancer Risk Stratification via Nondestructive 3D Pathology with Deep Learning–Assisted Gland Analysis
por: Xie, Weisi, et al.
Publicado: (2022)

Quantification of T- and B-cell Immune Receptor Distribution Diversity Characterizes Immune Cell Infiltration and Lymphocyte Heterogeneity in Clear Cell Renal Cell Carcinoma
por: Ferrall-Fairbanks, Meghan C., et al.
Publicado: (2022)

Quantitative Analysis of Tyrosine Phosphorylation from FFPE Tissues Reveals Patient-Specific Signaling Networks
por: Kohale, Ishwar N., et al.
Publicado: (2021)

Computational Analysis of Cholangiocarcinoma Phosphoproteomes Identifies Patient-Specific Drug Targets
por: Khorsandi, Shirin Elizabeth, et al.
Publicado: (2021)

A Microfluidic Cancer-on-Chip Platform Predicts Drug Response Using Organotypic Tumor Slice Culture
por: Chakrabarty, Sanjiban, et al.
Publicado: (2022)

Imaging Glioblastoma Response to Radiotherapy Using (2)H Magnetic Resonance Spectroscopy Measurements of Fumarate Metabolism
por: Hesse, Friederike, et al.
Publicado: (2022)

Delineating the RAS Conformational Landscape
por: Parker, Mitchell I., et al.
Publicado: (2022)

Photoacoustic Tomography Detects Response and Resistance to Bevacizumab in Breast Cancer Mouse Models
por: Quiros-Gonzalez, Isabel, et al.
Publicado: (2022)

Chemotherapy-Induced Collagen IV Drives Cancer Cell Motility through Activation of Src and Focal Adhesion Kinase
por: Fatherree, Jackson P., et al.
Publicado: (2022)

Quantitative Micro-Elastography Enables In Vivo Detection of Residual Cancer in the Surgical Cavity during Breast-Conserving Surgery
por: Gong, Peijun, et al.
Publicado: (2022)

A Cell-Fate Reprogramming Strategy Reverses Epithelial-to-Mesenchymal Transition of Lung Cancer Cells While Avoiding Hybrid States
por: Kim, Namhee, et al.
Publicado: (2023)

Stimulated Raman Scattering Microscopy Enables Gleason Scoring of Prostate Core Needle Biopsy by a Convolutional Neural Network
por: Ao, Jianpeng, et al.
Publicado: (2023)

Mathematical Modeling and Mutational Analysis Reveal Optimal Therapy to Prevent Malignant Transformation in Grade II IDH-Mutant Gliomas
por: Aoki, Kosuke, et al.
Publicado: (2021)

Bayesian Machine Learning Enables Identification of Transcriptional Network Disruptions Associated with Drug-Resistant Prostate Cancer
por: Blatti, Charles, et al.
Publicado: (2023)

Virtual reality for 3D histology: multi-scale visualization of organs with interactive feature exploration
por: Liimatainen, Kaisa, et al.
Publicado: (2021)

Spatial analysis of histology in 3D: quantification and visualization of organ and tumor level tissue environment
por: Ruusuvuori, Pekka, et al.
Publicado: (2022)

A Multi-Stain Breast Cancer Histological Whole-Slide-Image Data Set from Routine Diagnostics
por: Weitz, Philippe, et al.
Publicado: (2023)

Analysis of spatial heterogeneity in normal epithelium and preneoplastic alterations in mouse prostate tumor models
por: Valkonen, Mira, et al.
Publicado: (2017)

Polyunsaturated Fatty Acid–Bound α-Fetoprotein Promotes Immune Suppression by Altering Human Dendritic Cell Metabolism
por: Munson, Paul V., et al.
Publicado: (2023)

The Ratio of Key Metabolic Transcripts Is a Predictive Biomarker of Breast Cancer Metastasis to the Lung
por: Mathur, Deepti, et al.
Publicado: (2023)

Profiling the Somatic Mutational Landscape of Breast Tumors from Hispanic/Latina Women Reveals Conserved and Unique Characteristics
por: Ding, Yuan Chun, et al.
Publicado: (2023)

BRCA1 Insufficiency Induces a Hypersialylated Acidic Tumor Microenvironment That Promotes Metastasis and Immunotherapy Resistance
por: Shu, Xiaodong, et al.
Publicado: (2023)

Comparative analysis of tissue reconstruction algorithms for 3D histology
por: Kartasalo, Kimmo, et al.
Publicado: (2018)

Using deep learning to detect patients at risk for prostate cancer despite benign biopsies
por: Liu, Bojing, et al.
Publicado: (2022)

Perioperative plasma mitochondrial DNA dynamics and correlation with inflammation during infantile cardiopulmonary bypass
por: Xu, Fei, et al.
Publicado: (2017)

Morphometry of the triangle of Koch and position of the coronary sinus opening in cadaveric fetal hearts
por: Shanubhogue, Sharan, et al.
Publicado: (2017)

Methylenetetrahydrofolate reductase C677T and methionine synthase A2756G gene polymorphisms and associated risk of cardiovascular diseases: A study from Jammu region
por: Raina, Jyotdeep K., et al.
Publicado: (2016)

OpenPhi: an interface to access Philips iSyntax whole slide images for computational pathology
por: Mulliqi, Nita, et al.
Publicado: (2021)

Detection of perineural invasion in prostate needle biopsies with deep neural networks
por: Kartasalo, Kimmo, et al.
Publicado: (2022)

Genome-wide spatial expression profiling in formalin-fixed tissues
por: Gracia Villacampa, Eva, et al.
Publicado: (2021)

Interobserver reproducibility of perineural invasion of prostatic adenocarcinoma in needle biopsies
por: Egevad, Lars, et al.
Publicado: (2021)

Feature-based analysis of mouse prostatic intraepithelial neoplasia in histological tissue sections
por: Ruusuvuori, Pekka, et al.
Publicado: (2016)

The effect of neural network architecture on virtual H&E staining: Systematic assessment of histological feasibility
por: Khan, Umair, et al.
Publicado: (2023)

What do we still need to learn on digitally assessed biomarkers?
por: Acs, Balazs, et al.
Publicado: (2021)

Convergent adaptive evolution—how common, or how rare?
por: Wu, Chung-I, et al.
Publicado: (2020)

Morphological Features Extracted by AI Associated with Spatial Transcriptomics in Prostate Cancer
por: Chelebian, Eduard, et al.
Publicado: (2021)

Prostate Cancer Vascularity: Superb Microvascular Imaging Ultrasonography with Histopathology Correlation
por: Zhu, Yi-Cheng, et al.
Publicado: (2019)

Estimating diagnostic uncertainty in artificial intelligence assisted pathology using conformal prediction
por: Olsson, Henrik, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_52dpti7p2jqaaqhu58ubm6ep56