Inhibition of ERK5 Elicits Cellular Senescence in Melanoma via the Cyclin-Dependent Kinase Inhibitor p21

Melanoma is the deadliest skin cancer with a very poor prognosis in advanced stages. Although targeted and immune therapies have improved survival, not all patients benefit from these treatments. The mitogen-activated protein kinase ERK5 supports the growth of melanoma cells in vitro and in vivo. Ho...

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Detalles Bibliográficos
Autores principales: Tubita, Alessandro, Lombardi, Zoe, Tusa, Ignazia, Lazzeretti, Azzurra, Sgrignani, Giovanna, Papini, Dimitri, Menconi, Alessio, Gagliardi, Sinforosa, Lulli, Matteo, Dello Sbarba, Persio, Esparís-Ogando, Azucena, Pandiella, Atanasio, Stecca, Barbara, Rovida, Elisabetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Tumor Biology and Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9397638/
https://www.ncbi.nlm.nih.gov/pubmed/34799355
http://dx.doi.org/10.1158/0008-5472.CAN-21-0993

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