Aberrant Transcript Usage Is Associated with Homologous Recombination Deficiency and Predicts Therapeutic Response

BRCA1/2 mutations account for only a small fraction of homologous recombination (HR) deficiency (HRD) cases. Recently developed genomic HRD (gHRD) tests suffer confounding factors that cause low precision in predicting samples that will respond to PARP inhibitors and DNA damaging agents. Here we pre...

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Detalles Bibliográficos
Autores principales: Kang, Hyeon Gu, Hwangbo, Haeun, Kim, Myung Ji, Kim, Sinae, Lee, Eun Ji, Park, Min Ji, Kim, Jae-Weon, Kim, Byoung-Gie, Cho, Eun-Hae, Chang, Suhwan, Lee, Jung-Yun, Choi, Jung Kyoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Translational Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9397646/
https://www.ncbi.nlm.nih.gov/pubmed/34711610
http://dx.doi.org/10.1158/0008-5472.CAN-21-2023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9397646/
https://www.ncbi.nlm.nih.gov/pubmed/34711610
http://dx.doi.org/10.1158/0008-5472.CAN-21-2023

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