13-amino derivatives of dehydrocostus lactone display greatly enhanced selective toxicity against breast cancer cells and improved binding energies to protein kinases in silico

The biological activities of dehydrocostus lactone and its analogues are suggested to be mediated by the lactone ring and α,β-methylene-γ-lactone. However, few studies exist on the structure-activity relationship of 13-amino derivatives of dehydrocostus latone. In this study new 13-amino derivatives...

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Detalles Bibliográficos
Autores principales: Kemboi, Douglas, Langat, Moses K., Siwe-Noundou, Xavier, Tshiwawa, Tendamudzimu, Krause, Rui W. M., Davison, Candace, Smit, Christie Jane, de la Mare, Jo-Anne, Tembu, Vuyelwa Jacqueline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9397875/
https://www.ncbi.nlm.nih.gov/pubmed/35998145
http://dx.doi.org/10.1371/journal.pone.0271389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9397875/
https://www.ncbi.nlm.nih.gov/pubmed/35998145
http://dx.doi.org/10.1371/journal.pone.0271389

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