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Can genetics guide exercise prescriptions in osteoarthritis?
Osteoarthritis (OA) is the most common form of arthritis and has a multifactorial etiology. Current management for OA focuses on minimizing pain and functional loss, typically involving pharmacological, physical, psychosocial, and mind-body interventions. However, there remain challenges in determin...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9397982/ https://www.ncbi.nlm.nih.gov/pubmed/36188938 http://dx.doi.org/10.3389/fresc.2022.930421 |
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author | Espin-Garcia, Osvaldo Baghel, Madhu Brar, Navraj Whittaker, Jackie L. Ali, Shabana Amanda |
author_facet | Espin-Garcia, Osvaldo Baghel, Madhu Brar, Navraj Whittaker, Jackie L. Ali, Shabana Amanda |
author_sort | Espin-Garcia, Osvaldo |
collection | PubMed |
description | Osteoarthritis (OA) is the most common form of arthritis and has a multifactorial etiology. Current management for OA focuses on minimizing pain and functional loss, typically involving pharmacological, physical, psychosocial, and mind-body interventions. However, there remain challenges in determining which patients will benefit most from which interventions. Although exercise-based interventions are recommended as first-line treatments and are known to be beneficial for managing both the disease and illness of OA, the optimal exercise “prescription” is unknown, due in part to our limited understanding of the precise mechanisms underlying its action. Here we present our perspective on the potential role of genetics in guiding exercise prescription for persons with OA. We describe key publications in the areas of exercise and OA, genetics and OA, and exercise and genetics, and point to a paucity of knowledge at the intersection of exercise, genetics, and OA. We suggest there is emerging evidence to support the use of genetics and epigenetics to explain the beneficial effects of exercise for OA. We identify missing links in the existing research relating to exercise, genetics, and OA, and highlight epigenetics as a promising mechanism through which environmental exposures such as exercise may impact OA outcomes. We anticipate future studies will improve our understanding of how genetic and epigenetic factors mediate exercise-based interventions to support implementation and ultimately improve OA patient care. |
format | Online Article Text |
id | pubmed-9397982 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93979822022-09-29 Can genetics guide exercise prescriptions in osteoarthritis? Espin-Garcia, Osvaldo Baghel, Madhu Brar, Navraj Whittaker, Jackie L. Ali, Shabana Amanda Front Rehabil Sci Rehabilitation Sciences Osteoarthritis (OA) is the most common form of arthritis and has a multifactorial etiology. Current management for OA focuses on minimizing pain and functional loss, typically involving pharmacological, physical, psychosocial, and mind-body interventions. However, there remain challenges in determining which patients will benefit most from which interventions. Although exercise-based interventions are recommended as first-line treatments and are known to be beneficial for managing both the disease and illness of OA, the optimal exercise “prescription” is unknown, due in part to our limited understanding of the precise mechanisms underlying its action. Here we present our perspective on the potential role of genetics in guiding exercise prescription for persons with OA. We describe key publications in the areas of exercise and OA, genetics and OA, and exercise and genetics, and point to a paucity of knowledge at the intersection of exercise, genetics, and OA. We suggest there is emerging evidence to support the use of genetics and epigenetics to explain the beneficial effects of exercise for OA. We identify missing links in the existing research relating to exercise, genetics, and OA, and highlight epigenetics as a promising mechanism through which environmental exposures such as exercise may impact OA outcomes. We anticipate future studies will improve our understanding of how genetic and epigenetic factors mediate exercise-based interventions to support implementation and ultimately improve OA patient care. Frontiers Media S.A. 2022-07-29 /pmc/articles/PMC9397982/ /pubmed/36188938 http://dx.doi.org/10.3389/fresc.2022.930421 Text en Copyright © 2022 Espin-Garcia, Baghel, Brar, Whittaker and Ali. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Rehabilitation Sciences Espin-Garcia, Osvaldo Baghel, Madhu Brar, Navraj Whittaker, Jackie L. Ali, Shabana Amanda Can genetics guide exercise prescriptions in osteoarthritis? |
title | Can genetics guide exercise prescriptions in osteoarthritis? |
title_full | Can genetics guide exercise prescriptions in osteoarthritis? |
title_fullStr | Can genetics guide exercise prescriptions in osteoarthritis? |
title_full_unstemmed | Can genetics guide exercise prescriptions in osteoarthritis? |
title_short | Can genetics guide exercise prescriptions in osteoarthritis? |
title_sort | can genetics guide exercise prescriptions in osteoarthritis? |
topic | Rehabilitation Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9397982/ https://www.ncbi.nlm.nih.gov/pubmed/36188938 http://dx.doi.org/10.3389/fresc.2022.930421 |
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