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Outer membrane vesicles of Porphyromonas gingivalis trigger NLRP3 inflammasome and induce neuroinflammation, tau phosphorylation, and memory dysfunction in mice

BACKGROUND: Porphyromonas gingivalis (Pg), the keystone pathogen in chronic periodontitis, is reported to initiate Alzheimer’s disease pathologies in preclinical studies. However, the specific mechanisms and signaling pathways acting on the brain still need to be further explored. Outer membrane ves...

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Detalles Bibliográficos
Autores principales:	Gong, Ting, Chen, Qi, Mao, Hongchen, Zhang, Yao, Ren, Huan, Xu, Mengmeng, Chen, Hong, Yang, Deqin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cellular and Infection Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9397999/ https://www.ncbi.nlm.nih.gov/pubmed/36017373 http://dx.doi.org/10.3389/fcimb.2022.925435

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